Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | GRM8 | O00222 | 1/20 | 0.38 |
| ▸ | GRM6 | O15303 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7364664 | 0.87 | RARB (0.38) | ALDH1A1KDM4ECYP2C9CYP2C19GRM8 | |
| SCHEMBL7396689 | 0.87 | KMT2A (0.37) | POLBALDH1A1CYP1A2KDM4ECYP2C9 | |
| SCHEMBL7366774 | 0.87 | GRM2 (0.48) | GRM2GRM3 | |
| SCHEMBL7399248 | 0.87 | HSD17B10 (0.45) | ALDH1A1KDM4ECYP2C9CYP2C19GRM8 | |
| SCHEMBL7361669 | 0.87 | SMN1; SMN2 (0.42) | ALDH1A1KDM4ECYP2C9CYP2C19GRM8 | |
| SCHEMBL7360786 | 0.83 | LDHA (0.47) | ALDH1A1KDM4ECYP2C19MEN1KMT2A | |
| SCHEMBL7360104 | 0.80 | CYP1A2 (0.46) | CYP1A2SLC1A2 | |
| SCHEMBL7367342 | 0.79 | GRM2 (0.51) | KDM4ECYP2C9CYP2C19GRM8GRM6 | |
| SCHEMBL7398125 | 0.78 | GRM2 (0.48) | ALDH1A1CYP1A2GRM2GRM3KMT2A | |
| SCHEMBL7364857 | 0.77 | GRM2 (0.52) | CYP2C9GRM2GRM3ANPEPENPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0771196-A4 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 1997-09-03 | — | — | EP | disclosed |
| EP-0771196-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1997-05-07 | — | — | EP | disclosed |
| WO-1996007405-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1996-03-14 | — | — | WO | disclosed |