Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 5/20 | 0.51 |
| ▸ | PDE4A | P27815 | 4/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 6/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7368982 | 0.77 | CYP1A2 (0.42) | PDE4BPDE4APDE4CPDE4DLMNA | |
| SCHEMBL7366331 | 0.77 | KMT2A (0.43) | PDE4BPDE4APDE4CPDE4DLMNA | |
| SCHEMBL8478264 | 0.75 | LMNA (0.60) | PDE4BPDE4APDE4CPDE4DLMNA | |
| SCHEMBL6541679 | 0.73 | CA1 (0.38) | LMNATP53HPGDTSHRMAPK1 | |
| SCHEMBL8480289 | 0.72 | LMNA (0.60) | PDE4BPDE4APDE4CPDE4DLMNA | |
| SCHEMBL3126336 | 0.69 | PDE4B (0.49) | PDE4BPDE4APDE4CPDE4DLMNA | |
| SCHEMBL1917602 | 0.69 | CYP1A2 (0.66) | PDE4BPDE4APDE4CPDE4DLMNA | |
| SCHEMBL8479743 | 0.68 | PDE4A (1.00) | PDE4BPDE4APDE4CPDE4DLMNA | |
| SCHEMBL11005422 | 0.68 | PDE4A (0.72) | PDE4BPDE4APDE4CPDE4DLMNA | |
| SCHEMBL2481127 | 0.68 | NOTUM (0.45) | NPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244669-A1 | PYRAZOLOPYRAZINES AND THEIR USE AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001040230-A1 | PYRAZOLOPYRAZINES AND THEIR USE AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-06-07 | — | — | WO | disclosed |