Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.60 |
| ▸ | PDE4A | P27815 | 3/20 | 0.60 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.60 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.60 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8478264 | 0.88 | LMNA (0.60) | LMNAPDE4BPDE4APDE4CPDE4D | |
| SCHEMBL26626575 | 0.81 | LMNA (0.59) | LMNAPDE4BPDE4APDE4CPDE4D | |
| SCHEMBL23297265 | 0.81 | LMNA (0.59) | LMNAPDE4BPDE4APDE4CPDE4D | |
| SCHEMBL30984948 | 0.80 | PDE4B (0.55) | LMNAPDE4BPDE4APDE4CPDE4D | |
| SCHEMBL8474899 | 0.79 | HTT (0.54) | PDE4BSMN1; SMN2KDM4EHTTHSD17B10 | |
| SCHEMBL23752067 | 0.78 | ADORA3 (0.48) | SMN1; SMN2HPGDCYP2C9TSHRMAPK1 | |
| SCHEMBL1376637 | 0.76 | LMNA (1.00) | LMNAPDE4BPDE4APDE4CPDE4D | |
| SCHEMBL8479743 | 0.75 | PDE4A (1.00) | LMNAPDE4BPDE4APDE4CPDE4D | |
| SCHEMBL12595743 | 0.73 | PDE4A (0.78) | LMNAPDE4BPDE4APDE4CPDE4D | |
| SCHEMBL11005422 | 0.72 | PDE4A (0.72) | LMNAPDE4BPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5883090-A | Endothelin receptor antagonists | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1999-03-16 | — | — | US | disclosed |
| EP-0796250-A1 | PYRIDAZINONES AS ENDOTHELIN-RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1997-09-24 | — | — | EP | disclosed |
| WO-1997013758-A1 | PYRIDAZINONES AS ENDOTHELIN-RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-04-17 | — | — | WO | disclosed |