Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.60 |
| ▸ | ALPL | P05186 | 1/20 | 0.60 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.56 |
| ▸ | PDE4A | P27815 | 3/20 | 0.56 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.56 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.55 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.49 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8480289 | 0.88 | LMNA (0.60) | LMNAALPLPDE4BPDE4APDE4C | |
| SCHEMBL23297265 | 0.84 | LMNA (0.59) | LMNAALPLPDE4BPDE4APDE4C | |
| SCHEMBL26626575 | 0.84 | LMNA (0.59) | LMNAALPLPDE4BPDE4APDE4C | |
| SCHEMBL10259154 | 0.78 | HRH3 (0.73) | HRH3 | |
| SCHEMBL15657901 | 0.78 | ALPL (0.55) | LMNAALPLALDH1A1KDM4EHPGD | |
| SCHEMBL6229280 | 0.77 | ALPL (0.62) | ALPLALDH1A1KDM4EHPGDCYP1A1 | |
| SCHEMBL1376637 | 0.76 | LMNA (1.00) | LMNAALPLPDE4BPDE4APDE4C | |
| SCHEMBL13539286 | 0.75 | ALPL (1.00) | LMNAALPLALDH1A1KDM4EHPGD | |
| SCHEMBL7364378 | 0.75 | PDE4B (0.51) | LMNAALPLPDE4BPDE4APDE4C | |
| SCHEMBL16841246 | 0.72 | KDM4E (0.58) | LMNAALPLALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5883090-A | Endothelin receptor antagonists | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1999-03-16 | — | — | US | disclosed |