Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | OXTR | P30559 | 2/20 | 0.39 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7363438 | 0.78 | RXRA (0.43) | KDM4EGAAALDH1A1SMN1; SMN2RXFP1 | |
| SCHEMBL7371784 | 0.75 | KDM4E (0.60) | KDM4EGAAALDH1A1KMT2AMAPT | |
| SCHEMBL9754413 | 0.71 | PTGER3 (0.56) | KDM4EGAAALDH1A1SMN1; SMN2RXFP1 | |
| SCHEMBL9700651 | 0.69 | MAPT (0.35) | KDM4EGAAALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL2281556 | 0.67 | KDM4E (0.75) | KDM4ESMN1; SMN2MEN1KMT2AMAPT | |
| SCHEMBL12299467 | 0.66 | KDM4E (0.58) | KDM4EGAAALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL429049 | 0.66 | MAOB (0.67) | KDM4EALDH1A1CYP3A4 | |
| SCHEMBL9701615 | 0.66 | KMT2A (0.59) | KDM4EALDH1A1SMN1; SMN2NPC1MEN1 | |
| SCHEMBL23022212 | 0.65 | KDM4E (0.57) | KDM4EGAANPC1POLBMEN1 | |
| SCHEMBL14356128 | 0.65 | MAOB (0.66) | KDM4EMAPTLMNACYP3A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0613467-A1 | 2-PYRIDINOL DERIVATIVES AND THEIR USE AS MEDICAMENTS | SMITHKLINE BEECHAM PLC (GB) | 1994-09-07 | — | — | EP | disclosed |
| WO-1993010093-A1 | 2-PYRIDINOL DERIVATIVES AND THEIR USE AS MEDICAMENTS | SMITHKLINE BEECHAM PLC (GB) | 1993-05-27 | — | — | WO | disclosed |