Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 2/20 | 0.43 |
| ▸ | RXRB | P28702 | 2/20 | 0.43 |
| ▸ | RXRG | P48443 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7364453 | 0.78 | KDM4E (0.45) | PTGS2MAPTHSD17B10ESR2KDM4E | |
| SCHEMBL9534054 | 0.73 | PTGER3 (0.53) | HSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL21437911 | 0.69 | POLB (0.51) | MAPTHSD17B10KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL11070050 | 0.69 | HSD17B10 (0.50) | MAPTHSD17B10KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL23352167 | 0.68 | THRB (0.61) | RXRARXRBRXRGPTGS2MAPT | |
| SCHEMBL7364529 | 0.68 | HSD17B10 (0.40) | MAPTHSD17B10KDM4EGAAALDH1A1 | |
| SCHEMBL7364525 | 0.68 | HSD17B10 (0.40) | MAPTHSD17B10KDM4EGAAALDH1A1 | |
| SCHEMBL9700651 | 0.68 | MAPT (0.35) | PTGS2MAPTHSD17B10ESR2KDM4E | |
| SCHEMBL21686586 | 0.65 | RXRA (0.58) | RXRARXRBPTGS2MAPTHSD17B10 | |
| SCHEMBL13802494 | 0.65 | PTGER1 (0.57) | RXRARXRBPTGS2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0613467-A1 | 2-PYRIDINOL DERIVATIVES AND THEIR USE AS MEDICAMENTS | SMITHKLINE BEECHAM PLC (GB) | 1994-09-07 | — | — | EP | claimed |
| WO-1993010093-A1 | 2-PYRIDINOL DERIVATIVES AND THEIR USE AS MEDICAMENTS | SMITHKLINE BEECHAM PLC (GB) | 1993-05-27 | — | — | WO | claimed |
| EP-0613467-A1 | 2-PYRIDINOL DERIVATIVES AND THEIR USE AS MEDICAMENTS | SMITHKLINE BEECHAM PLC (GB) | 1994-09-07 | — | — | EP | disclosed |
| WO-1993010093-A1 | 2-PYRIDINOL DERIVATIVES AND THEIR USE AS MEDICAMENTS | SMITHKLINE BEECHAM PLC (GB) | 1993-05-27 | — | — | WO | disclosed |