Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA9 | Q16790 | 7/20 | 0.74 |
| ▸ | CA12 | O43570 | 6/20 | 0.74 |
| ▸ | CXCR3 | P49682 | 2/20 | 0.72 |
| ▸ | TAS2R14 | Q9NYV8 | 3/20 | 0.65 |
| ▸ | TP53 | P04637 | 1/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | CA1 | P00915 | 4/20 | 0.61 |
| ▸ | CA2 | P00918 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 3/20 | 0.57 |
| ▸ | RAB9A | P51151 | 3/20 | 0.57 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.57 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8087744 | 0.94 | CXCR3 (0.71) | CA9CA12CXCR3TAS2R14TP53 | |
| SCHEMBL8087629 | 0.85 | CA9 (1.00) | CA9CA12CXCR3TP53NPSR1 | |
| SCHEMBL8090795 | 0.85 | CXCR3 (0.68) | CA9CA12CXCR3TAS2R14ALDH1A1 | |
| SCHEMBL12863085 | 0.84 | CXCR3 (1.00) | CA9CA12CXCR3TAS2R14ALDH1A1 | |
| SCHEMBL31337910 | 0.82 | TAS2R14 (0.69) | CA9CA12CXCR3TAS2R14ALDH1A1 | |
| SCHEMBL9416606 | 0.81 | NPC1 (0.82) | CXCR3NPSR1ALDH1A1CA1CA2 | |
| SCHEMBL11761142 | 0.81 | NPC1 (0.82) | CXCR3NPSR1ALDH1A1CA1CA2 | |
| SCHEMBL1169340 | 0.80 | CXCR3 (0.90) | CA9CA12CXCR3TAS2R14TP53 | |
| SCHEMBL6824910 | 0.79 | CA9 (0.58) | CA9CA12CXCR3TP53NPSR1 | |
| SCHEMBL1279042 | 0.79 | TAS2R14 (1.00) | CA9CA12CXCR3TAS2R14CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1200397-A1 | SULFONAMIDE SUBSTITUTED BENZYLAMINE DERIVATIVES AND THEIR USE AS MEDICAMENTS | ELI LILLY AND COMPANY LIMITED (GB) | 2002-05-02 | — | — | EP | disclosed |
| WO-2001004087-A1 | SULFONAMIDE SUBSTITUTED BENZYLAMINE DERIVATIVES AND THEIR USE AS MEDICAMENTS | ELI LILLY AND COMPANY LIMITED (GB) | 2001-01-18 | — | — | WO | disclosed |
| EP-1047670-A1 | AMINOSULPHONYLBENZAMIDE DERIVATIVES AS MODULATORS OF THE ACTIVITY OF NEURONAL CALCIUM CHANNELS | ELI LILLY AND COMPANY LIMITED (GB) | 2000-11-02 | — | — | EP | disclosed |
| WO-1999036398-A1 | AMINOSULPHONYLBENZAMIDE DERIVATIVES AS MODULATORS OF THE ACTIVITY OF NEURONAL CALCIUM CHANNELS | ELI LILLY AND COMPANY LIMITED (GB) | 1999-07-22 | — | — | WO | disclosed |