Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | MCOLN3 | Q8TDD5 | 2/20 | 0.50 |
| ▸ | PDE4A | P27815 | 1/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9757285 | 0.79 | PKM (0.51) | CYP2C19SMN1; SMN2TSHRPOLBHTT | |
| SCHEMBL28485965 | 0.77 | CYP3A4 (0.49) | CYP3A4CYP2C19SMN1; SMN2NPSR1GPBAR1 | |
| SCHEMBL28485032 | 0.77 | CYP3A4 (0.49) | CYP3A4CYP2C19SMN1; SMN2NPSR1GPBAR1 | |
| SCHEMBL3830421 | 0.77 | GPBAR1 (0.90) | CYP3A4CYP2C19SMN1; SMN2NPSR1GPBAR1 | |
| SCHEMBL4184681 | 0.77 | GPBAR1 (0.90) | CYP3A4CYP2C19SMN1; SMN2NPSR1GPBAR1 | |
| SCHEMBL28488424 | 0.77 | CYP3A4 (0.48) | CYP3A4CYP2C19SMN1; SMN2NPSR1GPBAR1 | |
| SCHEMBL6186477 | 0.77 | HTR6 (0.58) | CYP3A4CYP2C19SMN1; SMN2NPSR1TSHR | |
| SCHEMBL6429647 | 0.76 | CYP3A4 (1.00) | CYP3A4CYP2C19SMN1; SMN2NPSR1GPBAR1 | |
| SCHEMBL28482926 | 0.75 | CYP3A4 (0.49) | CYP3A4CYP2C19SMN1; SMN2NPSR1GPBAR1 | |
| SCHEMBL28492863 | 0.75 | CYP3A4 (0.49) | CYP3A4CYP2C19SMN1; SMN2NPSR1GPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996036611-A1 | 3,4-DISUBSTITUTED-PHENYLSULPHONAMIDES AND THEIR THERAPEUTIC USE | CHIROSCIENCE LIMITED (GB) | 1996-11-21 | — | — | WO | claimed |
| US-5728712-A | 3,4-disubstituted-phenylsulphonamides and their therapeutic use | CHIROSCIENCE LIMITED (GB) | 1998-03-17 | — | — | US | disclosed |
| WO-1996036611-A1 | 3,4-DISUBSTITUTED-PHENYLSULPHONAMIDES AND THEIR THERAPEUTIC USE | CHIROSCIENCE LIMITED (GB) | 1996-11-21 | — | — | WO | disclosed |