Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 3/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6903991 | 0.78 | LMNA (0.53) | LMNAPRMT5BACE1DYRK1ACYP3A4 | |
| SCHEMBL7368978 | 0.74 | LMNA (0.61) | LMNABACE1CYP3A4PKMMAPT | |
| SCHEMBL310511 | 0.70 | LMNA (0.67) | LMNABACE1DYRK1ACYP3A4MAPT | |
| SCHEMBL8673305 | 0.69 | LMNA (0.37) | LMNACYP3A4PKMMAPTHTT | |
| SCHEMBL3238859 | 0.69 | GPR3 (0.45) | LMNACYP3A4PKMMAPTHTT | |
| SCHEMBL28126432 | 0.69 | LMNA (0.65) | LMNABACE1DYRK1ACYP3A4MAPT | |
| SCHEMBL28007256 | 0.69 | LMNA (0.65) | LMNABACE1DYRK1ACYP3A4MAPT | |
| SCHEMBL8669721 | 0.68 | KDM4E (0.40) | LMNADYRK1ACYP3A4PKMMAPT | |
| SCHEMBL1900105 | 0.67 | LMNA (0.67) | LMNACYP3A4PKMMAPTHSP90AA1 | |
| SCHEMBL3820324 | 0.67 | LMNA (0.43) | LMNACYP3A4PKMMAPTHSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0828742-B1 | DIAZEPINO-INDOLES AS PHOSPHODIESTERASE IV INHIBITORS | JOUVEINAL INST RECH (FR) | 2001-12-19 | — | — | EP | claimed |
| EP-1132390-A2 | Diazepinoindoles as phophodiesterase inhibitors | INSTITUT DE RECHERCHE JOUVEINAL (FR) | 2001-09-12 | — | — | EP | claimed |
| US-5972927-A | ANTIINFLAMMATORY, ANTIALLERGIC AND BRONCHODILATORY MEDICINAL PRODUCTS, TREATMENT OF ASTHMA | JOUVEINAL (FR) | 1999-10-26 | — | — | US | claimed |
| EP-0828742-A1 | DIAZEPINO-INDOLES AS PHOSPHODIESTERASE IV INHIBITORS | INSTITUT DE RECHERCHE JOUVEINAL (I.R.J) (FR) | 1998-03-18 | — | — | EP | claimed |
| WO-1997036905-A1 | DIAZEPINO-INDOLES AS PHOSPHODIESTERASE IV INHIBITORS | INSTITUT DE RECHERCHE JOUVEINAL (FR) | 1997-10-09 | — | — | WO | claimed |
| EP-0828742-B1 | DIAZEPINO-INDOLES AS PHOSPHODIESTERASE IV INHIBITORS | JOUVEINAL INST RECH (FR) | 2001-12-19 | — | — | EP | disclosed |
| EP-1132390-A2 | Diazepinoindoles as phophodiesterase inhibitors | INSTITUT DE RECHERCHE JOUVEINAL (FR) | 2001-09-12 | — | — | EP | disclosed |
| US-5972927-A | ANTIINFLAMMATORY, ANTIALLERGIC AND BRONCHODILATORY MEDICINAL PRODUCTS, TREATMENT OF ASTHMA | JOUVEINAL (FR) | 1999-10-26 | — | — | US | disclosed |
| EP-0828742-A1 | DIAZEPINO-INDOLES AS PHOSPHODIESTERASE IV INHIBITORS | INSTITUT DE RECHERCHE JOUVEINAL (I.R.J) (FR) | 1998-03-18 | — | — | EP | disclosed |
| WO-1997036905-A1 | DIAZEPINO-INDOLES AS PHOSPHODIESTERASE IV INHIBITORS | INSTITUT DE RECHERCHE JOUVEINAL (FR) | 1997-10-09 | — | — | WO | disclosed |