Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.39 |
| ▸ | EDNRB | P24530 | 9/20 | 0.37 |
| ▸ | EDNRA | P25101 | 9/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 3/20 | 0.35 |
| ▸ | PPARD | Q03181 | 2/20 | 0.35 |
| ▸ | PPARA | Q07869 | 2/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7444988 | 1.00 | AAK1 (0.39) | AAK1EDNRBEDNRACYP1A2CYP2D6 | |
| SCHEMBL28584476 | 0.84 | PPARG (0.45) | AAK1KMT2AMEN1NPC1MMP8 | |
| SCHEMBL7222441 | 0.82 | PPARG (0.43) | AAK1KMT2AMEN1NPC1MMP8 | |
| SCHEMBL7400423 | 0.79 | CES2 (0.44) | AAK1KMT2AMEN1NPC1MMP8 | |
| SCHEMBL5151578 | 0.79 | CES2 (0.44) | AAK1KMT2AMEN1NPC1MMP8 | |
| SCHEMBL21879161 | 0.77 | AAK1 (0.40) | AAK1CYP1A2CYP2C9KMT2AMEN1 | |
| SCHEMBL8983584 | 0.77 | MAPT (0.48) | KMT2AMEN1NPC1 | |
| SCHEMBL5310601 | 0.77 | AAK1 (0.46) | AAK1KMT2AMEN1NPC1MMP8 | |
| SCHEMBL7445181 | 0.76 | TPH1 (0.47) | EDNRBEDNRACYP1A2CYP2D6CYP19A1 | |
| SCHEMBL7360008 | 0.76 | TPH1 (0.47) | EDNRBEDNRACYP1A2CYP2D6CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5780498-A | PEPTIDE DERIVATIVES FOR CARDIOVASCULAR AND BRAIN DISORDERS | CIBA-GEIGY JAPAN LIMITED (JP) | 1998-07-14 | — | — | US | disclosed |
| US-5703106-A | TREATING VARIOUS CARDIOVASCULAR, UROGENITAL, BRAIN DISORDERS | JAPAT LTD. (CH) | 1997-12-30 | — | — | US | disclosed |
| WO-1997011960-A1 | ANTAGONISTS OF ENDOTHELIN RECEPTORS | JAPAT LTD. (CH) | 1997-04-03 | — | — | WO | disclosed |
| CN-1145075-A | Antagonist's of endothelin receptors | JAPAT LTD (CH) | 1997-03-12 | — | — | CN | disclosed |
| EP-0753004-A1 | ANTAGONISTS OF ENDOTHELIN RECEPTORS | Japat Ltd (CH) | 1997-01-15 | — | — | EP | disclosed |
| EP-0728145-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | Ciba-Geigy Japan Limited (JP) | 1996-08-28 | — | — | EP | disclosed |
| WO-1995026360-A1 | ANTAGONISTS OF ENDOTHELIN RECEPTORS | JAPAT LTD. (CH) | 1995-10-05 | — | — | WO | disclosed |
| WO-1995012611-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | JAPAT LTD. (CH) | 1995-05-11 | — | — | WO | disclosed |