SCHEMBL7364971

SCHEMBL7364971

Cc1ccc(S(=O)(=O)c2nc3ccc(C(=O)O)cc3[nH]2)cc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 2/20 0.58
HSP90AA1 P07900 1/20 0.58
ESR2 Q92731 1/20 0.58
CHEK2 O96017 6/20 0.56
GAA P10253 2/20 0.53
HSD17B10 Q99714 1/20 0.53
SMN1; SMN2 Q16637 2/20 0.48
NPSR1 Q6W5P4 1/20 0.48
PIN1 Q13526 1/20 0.48
TP53 P04637 1/20 0.46
APEX1 P27695 1/20 0.46
ALDH1A1 P00352 3/20 0.46
HPGD P15428 2/20 0.46
MAPT P10636 2/20 0.46
KDM4E B2RXH2 1/20 0.46
NR4A2 P43354 1/20 0.45
MAPK1 P28482 1/20 0.44
POLB P06746 2/20 0.44
RAB9A P51151 1/20 0.44
MEN1 O00255 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12967679 0.81 HSP90AA1 (0.63) TDP1HSP90AA1ESR2CHEK2GAA
SCHEMBL6756159 0.76 L3MBTL1 (0.57) GAAHSD17B10SMN1; SMN2NPSR1TP53
SCHEMBL11564587 0.76 CHEK2 (0.78) TDP1HSP90AA1ESR2CHEK2NR4A2
SCHEMBL29924530 0.74 TDP1 (1.00) TDP1HSP90AA1ESR2CHEK2SMN1; SMN2
SCHEMBL1758956 0.74 TDP1 (1.00) TDP1HSP90AA1ESR2CHEK2SMN1; SMN2
Hydrochloric Acid SCHEMBL7331913 0.73 TDP1 (0.97) TDP1HSP90AA1ESR2CHEK2SMN1; SMN2
SCHEMBL7316384 0.72 ALDH1A1 (0.71) TDP1GAASMN1; SMN2TP53ALDH1A1
Guanidine SCHEMBL8688480 0.72 CHEK2 (0.69) CHEK2NR4A2
SCHEMBL6376038 0.71 GAA (0.43) HSP90AA1GAAHSD17B10NPSR1ALDH1A1
SCHEMBL9305236 0.71 HSP90AA1 (0.66) TDP1HSP90AA1ESR2CHEK2SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1019045-A4 ANTITHROMBOTIC AGENTS LILLY CO ELI (US) 2002-07-03 EP disclosed
EP-1019045-A1 ANTITHROMBOTIC AGENTS ELI LILLY AND COMPANY (US) 2000-07-19 EP disclosed
WO-1999000128-A1 ANTITHROMBOTIC AGENTS ELI LILLY AND COMPANY (US) 1999-01-07 WO disclosed