Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 4/20 | 0.47 |
| ▸ | TDO2 | P48775 | 7/20 | 0.40 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.37 |
| ▸ | TUBB | P07437 | 2/20 | 0.37 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.37 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.37 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.37 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.37 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.37 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.37 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.37 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.37 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.37 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.37 |
| ▸ | TUBB6 | Q9BUF5 | 2/20 | 0.37 |
| ▸ | TUBB2B | Q9BVA1 | 2/20 | 0.37 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL757235 | 0.83 | IDO1 (0.52) | IDO1TDO2GPR84HTR2ATUBB4A | |
| SCHEMBL736880 | 0.78 | IDO1 (0.49) | IDO1TDO2GPR84HTR2ATUBB4A | |
| SCHEMBL735392 | 0.78 | IDO1 (0.49) | IDO1GPR84HTR2ATUBB4ATUBB | |
| SCHEMBL736507 | 0.78 | IDO1 (0.49) | IDO1GPR84HTR2ATUBB4ATUBB | |
| SCHEMBL3190247 | 0.78 | HTR2A (0.50) | IDO1GPR84HTR2AHTR1ASLC6A2 | |
| SCHEMBL3191522 | 0.78 | SLC6A4 (0.60) | IDO1GPR84SLC6A2SLC6A4 | |
| SCHEMBL736864 | 0.78 | IDO1 (0.49) | IDO1GPR84HTR2AHTR1ASLC6A2 | |
| SCHEMBL735716 | 0.76 | HTR2A (0.62) | IDO1GPR84HTR2AHTR1ASLC6A2 | |
| SCHEMBL4391470 | 0.76 | MPO (0.54) | IDO1GPR84HTR2AHTR1ASLC6A4 | |
| SCHEMBL4392323 | 0.75 | MPO (0.57) | IDO1GPR84HTR2AHTR1ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138220-B2 | [2-(6-fluoro-1H-indol-3-ylsulfanyl)benzyl]methyl amine for the treatment of affective disorders | H. LUNDBECK A/S (DK) | 2012-03-20 | — | — | US | claimed |
| US-20090326036-A1 | [2-(6-FLUORO-1H-INDOL-3-YLSULFANYL)BENZYL]METHYL AMINE FOR THE TREATMENT OF AFFECTIVE DISORDERS | H. LUNDBECK A/S (DK) | 2009-12-31 | — | — | US | claimed |
| EP-2074091-A1 | [2-(6-FLOURO-1H-INDOL-3-YLSULFANYL)BENZYL]METHYL AMINE FOR THE TREATMENT OF AFFECTIVE DISORDERS | H. Lundbeck A/S (DK) | 2009-07-01 | — | — | EP | claimed |
| WO-2008037258-A1 | [2-(6-FLOURO-1H-INDOL-3-YLSULFANYL)BENZYL]METHYL AMINE FOR THE TREATMENT OF AFFECTIVE DISORDERS | H. LUNDBECK A/S (DK) | 2008-04-03 | — | — | WO | claimed |
| US-8138220-B2 | [2-(6-fluoro-1H-indol-3-ylsulfanyl)benzyl]methyl amine for the treatment of affective disorders | H. LUNDBECK A/S (DK) | 2012-03-20 | — | — | US | disclosed |
| US-8138220-B2 | [2-(6-fluoro-1H-indol-3-ylsulfanyl)benzyl]methyl amine for the treatment of affective disorders | H. LUNDBECK A/S (DK) | 2012-03-20 | — | — | US | disclosed |
| US-8138220-B2 | [2-(6-fluoro-1H-indol-3-ylsulfanyl)benzyl]methyl amine for the treatment of affective disorders | H. LUNDBECK A/S (DK) | 2012-03-20 | — | — | US | disclosed |
| US-20090326036-A1 | [2-(6-FLUORO-1H-INDOL-3-YLSULFANYL)BENZYL]METHYL AMINE FOR THE TREATMENT OF AFFECTIVE DISORDERS | H. LUNDBECK A/S (DK) | 2009-12-31 | — | — | US | disclosed |
| US-20090326036-A1 | [2-(6-FLUORO-1H-INDOL-3-YLSULFANYL)BENZYL]METHYL AMINE FOR THE TREATMENT OF AFFECTIVE DISORDERS | H. LUNDBECK A/S (DK) | 2009-12-31 | — | — | US | disclosed |
| US-20090326036-A1 | [2-(6-FLUORO-1H-INDOL-3-YLSULFANYL)BENZYL]METHYL AMINE FOR THE TREATMENT OF AFFECTIVE DISORDERS | H. LUNDBECK A/S (DK) | 2009-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090326036-A1 | [2-(6-FLUORO-1H-INDOL-3-YLSULFANYL)BENZYL]METHYL AMINE FOR THE TREATMENT OF AFFECTIVE DISORDERS | HTR2C, HTR3B, HTR3C | IDO1 108/4885TDO2 627/4885GPR84 3810/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.