Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.62 |
| ▸ | MPO | P05164 | 9/20 | 0.51 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.42 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | HTR1D | P28221 | 1/20 | 0.42 |
| ▸ | HTR1B | P28222 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1399332 | 0.90 | MPO (0.62) | HTR2AMPOTRPM8HTR1AKMT2A | |
| SCHEMBL4632232 | 0.90 | HTR2A (0.65) | HTR2AMPOTRPM8HTR1AKMT2A | |
| SCHEMBL3190247 | 0.90 | HTR2A (0.50) | HTR2AMPOTRPM8HTR1AKMT2A | |
| Cadaverine Tartrate SCHEMBL736178 | 0.89 | HTR2A (0.50) | HTR2AMPOTRPM8HTR1AKMT2A | |
| SCHEMBL4632768 | 0.87 | HTR2A (0.47) | HTR2AMPOTRPM8HTR1AKMT2A | |
| SCHEMBL3190980 | 0.85 | HTR2A (0.51) | HTR2AMPOTRPM8HTR1AKMT2A | |
| SCHEMBL3175043 | 0.85 | HTR2A (0.51) | HTR2AMPOTRPM8HTR1AKMT2A | |
| SCHEMBL736880 | 0.84 | IDO1 (0.49) | HTR2AHTR1AIDO1GPR84GFER | |
| SCHEMBL757235 | 0.84 | IDO1 (0.52) | HTR2AHTR1AIDO1GPR84GFER | |
| SCHEMBL736507 | 0.84 | IDO1 (0.49) | HTR2AHTR1AIDO1GPR84GFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074091-B1 | [2-(6-FLOURO-1H-INDOL-3-YLSULFANYL)BENZYL]METHYL AMINE FOR THE TREATMENT OF AFFECTIVE DISORDERS | LUNDBECK & CO AS H (DK) | 2015-01-07 | — | — | EP | claimed |
| US-7737170-B2 | Uses of 2-(1H-indolylsulfanyl)-benzyl amine derivatives as SSRIS | H. LUNDBECK A/S (DK) | 2010-06-15 | — | — | US | claimed |
| US-20090326036-A1 | [2-(6-FLUORO-1H-INDOL-3-YLSULFANYL)BENZYL]METHYL AMINE FOR THE TREATMENT OF AFFECTIVE DISORDERS | H. LUNDBECK A/S (DK) | 2009-12-31 | — | — | US | claimed |
| WO-2009112541-A2 | [2-(6-FLOURO-1H-INDOL-3-YLSULFANYL)BENZYL]METHYL AMINE FOR THE TREATMENT OF AFFECTIVE DISORDERS | H. LUNDBECK A/S (DK) | 2009-09-17 | — | — | WO | claimed |
| US-7563908-B2 | 2-(1H-indolylsulfanyl)-benzyl amine derivatives as SSRI | H. LUNDBECK A/S (DK) | 2009-07-21 | — | — | US | claimed |
| EP-2074091-A1 | [2-(6-FLOURO-1H-INDOL-3-YLSULFANYL)BENZYL]METHYL AMINE FOR THE TREATMENT OF AFFECTIVE DISORDERS | H. Lundbeck A/S (DK) | 2009-07-01 | — | — | EP | claimed |
| US-20080214645-A1 | USES OF 2-(1H-INDOLYLSULFANYL)-BENZYL AMINE DERIVATIVES AS SSRIS | H. LUNDBECK A/S (DK) | 2008-09-04 | — | — | US | claimed |
| EP-1701940-B1 | 2-(1H-INDOLYLSULFANYL)-BENZYL AMINE DERIVATIVES AS SSRI | LUNDBECK & CO AS H (DK) | 2008-05-28 | — | — | EP | claimed |
| WO-2008037258-A1 | [2-(6-FLOURO-1H-INDOL-3-YLSULFANYL)BENZYL]METHYL AMINE FOR THE TREATMENT OF AFFECTIVE DISORDERS | H. LUNDBECK A/S (DK) | 2008-04-03 | — | — | WO | claimed |
| EP-1860100-A2 | 2-(1H-indolylsulfanyl)-benzyl amine derivatives as SSRI | H. Lundbeck A/S (DK) | 2007-11-28 | — | — | EP | claimed |
| US-20060160880-A1 | 2-(1H-indolylsulfanyl)-benzyl amine derivatives as SSRI | H. LUNDBECK A/S (DK) | 2006-07-20 | — | — | US | claimed |
| US-20230068400-A1 | TAFA4 POLYPEPTIDE OR POLYNUCLEOTIDE FOR TREATING INFLAMMATORY DISEASE | UNIVERSITE D'AIX MARSEILLE (FR) | 2023-03-02 | — | — | US | disclosed |
| US-10767226-B2 | Honeycomb tube | CEPHEID (US) | 2020-09-08 | — | — | US | disclosed |
| EP-2074091-B1 | [2-(6-FLOURO-1H-INDOL-3-YLSULFANYL)BENZYL]METHYL AMINE FOR THE TREATMENT OF AFFECTIVE DISORDERS | LUNDBECK & CO AS H (DK) | 2015-01-07 | — | — | EP | disclosed |
| EP-2074091-B1 | [2-(6-FLOURO-1H-INDOL-3-YLSULFANYL)BENZYL]METHYL AMINE FOR THE TREATMENT OF AFFECTIVE DISORDERS | LUNDBECK & CO AS H (DK) | 2015-01-07 | — | — | EP | disclosed |
| WO-2008037258-A1 | [2-(6-FLOURO-1H-INDOL-3-YLSULFANYL)BENZYL]METHYL AMINE FOR THE TREATMENT OF AFFECTIVE DISORDERS | H. LUNDBECK A/S (DK) | 2008-04-03 | — | — | WO | disclosed |
| EP-1860100-A2 | 2-(1H-indolylsulfanyl)-benzyl amine derivatives as SSRI | H. Lundbeck A/S (DK) | 2007-11-28 | — | — | EP | disclosed |
| EP-1701940-A1 | 2-(1H-INDOLYLSULFANYL)-BENZYL AMINE DERIVATIVES AS SSRI | H.Lundbeck A/S (DK) | 2006-09-20 | — | — | EP | disclosed |
| US-20060160880-A1 | 2-(1H-indolylsulfanyl)-benzyl amine derivatives as SSRI | H. LUNDBECK A/S (DK) | 2006-07-20 | — | — | US | disclosed |
| WO-2005061455-A1 | 2-(1H-INDOLYLSULFANYL)-BENZYL AMINE DERIVATIVES AS SSRI | H. LUNDBECK A/S (DK) | 2005-07-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060160880-A1 | 2-(1H-indolylsulfanyl)-benzyl amine derivatives as SSRI | TPH1, TPH2, HTR2B | HTR2A 8/4885MPO 2722/4885TRPM8 4087/4885 |
| US-20080214645-A1 | USES OF 2-(1H-INDOLYLSULFANYL)-BENZYL AMINE DERIVATIVES AS SSRIS | TPH2, TPH1, HTR1B | HTR2A 8/4885MPO 3142/4885TRPM8 3588/4885 |
| US-20090326036-A1 | [2-(6-FLUORO-1H-INDOL-3-YLSULFANYL)BENZYL]METHYL AMINE FOR THE TREATMENT OF AFFECTIVE DISORDERS | HTR2C, HTR3B, HTR3C | HTR2A 4/4885MPO 3918/4885TRPM8 2487/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.