Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 6/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.48 |
| ▸ | CACNA1C | Q13936 | 4/20 | 0.48 |
| ▸ | TSHR | P16473 | 4/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.48 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.48 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.48 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.48 |
| ▸ | SCN1A | P35498 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7400294 | 0.89 | MAPT (0.46) | MAPTCYP1A2ADORA3CYP3A4CYP2C9 | |
| SCHEMBL9280838 | 0.88 | HPGD (0.48) | MAPTCYP1A2ADORA3CYP3A4CYP2C9 | |
| SCHEMBL7406051 | 0.88 | ADORA3 (0.53) | MAPTCYP1A2ADORA3CYP3A4CYP2C9 | |
| SCHEMBL9248478 | 0.85 | ADORA3 (0.61) | MAPTCYP1A2ADORA3CYP3A4CYP2C9 | |
| SCHEMBL7390505 | 0.81 | MAPT (0.56) | MAPTTSHRKDM4EHSD17B10POLB | |
| SCHEMBL7445246 | 0.80 | ADORA3 (0.60) | MAPTCYP1A2ADORA3CYP3A4CYP2C9 | |
| SCHEMBL7365819 | 0.79 | CYP1A2 (0.58) | MAPTCYP1A2ADORA3CYP3A4CYP2C9 | |
| SCHEMBL7393785 | 0.79 | CYP1A2 (0.58) | MAPTCYP1A2ADORA3CYP3A4CYP2C9 | |
| SCHEMBL7396706 | 0.79 | CYP1A2 (0.58) | MAPTCYP1A2ADORA3CYP3A4CYP2C9 | |
| SCHEMBL10692951 | 0.78 | ADORA3 (0.53) | MAPTCYP1A2ADORA3CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995013812-A1 | USE OF SUBSTITUTED 1,4-DIHYDROPYRIDINE TO REDUCE INTRAOCULAR PRESSURE | BYK NEDERLAND BV (NL) | 1995-05-26 | — | — | WO | claimed |
| US-5378718-A | Cardiovascular activity, hypotensive | CEDONA PHARMACEUTICALS B.V. (NL) | 1995-01-03 | — | — | US | disclosed |
| WO-1992002503-A1 | NOVEL 1,4-DIHYDROPYRIDINE DERIVATIVES | CEDONA PHARMACEUTICALS BV (NL) | 1992-02-20 | — | — | WO | disclosed |