Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | PARP1 | P09874 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | CES2 | O00748 | 2/20 | 0.42 |
| ▸ | CES1 | P23141 | 2/20 | 0.42 |
| ▸ | DAO | P14920 | 1/20 | 0.42 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1750474 | 0.82 | TDP1 (0.54) | CYP2C19TSHRTDP1MAPTPOLB | |
| SCHEMBL543877 | 0.81 | CES1 (0.55) | CYP2C19TSHRTDP1MAPTPOLB | |
| SCHEMBL2880519 | 0.78 | MAPT (0.50) | CYP2C19TSHRTDP1MAPTPOLB | |
| SCHEMBL3784819 | 0.77 | CES1 (0.50) | CYP2C19TSHRTDP1MAPTPOLB | |
| Thioacetamide SCHEMBL11747863 | 0.75 | MAPT (0.46) | CYP2C19TSHRTDP1MAPTPOLB | |
| SCHEMBL3035866 | 0.73 | CES2 (0.50) | CYP2C19TSHRTDP1MAPTPOLB | |
| SCHEMBL828587 | 0.73 | TPH1 (0.55) | CYP2C19TSHRTDP1MAPTPOLB | |
| SCHEMBL732449 | 0.72 | TDP1 (0.52) | CYP2C19TSHRTDP1MAPTPOLB | |
| SCHEMBL743301 | 0.72 | CES1 (0.50) | CYP2C19TSHRTDP1MAPTPOLB | |
| SCHEMBL2950166 | 0.72 | CES1 (0.50) | CYP2C19TSHRTDP1MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0355612-B1 | Furylthiazole derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1994-07-27 | — | — | EP | claimed |
| US-4822805-A | ANTIINFLAMMATORY AGENTS, CARDIOTONIC AGENTS, ANTIPLATELET AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-04-18 | — | — | US | claimed |
| EP-0257897-A1 | Imidazole compounds, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-03-02 | — | — | EP | claimed |
| EP-3386988-A1 | NOVEL DIHYDROPYRANOPYRIMIDINONE DERIVATIVES, AND USE THEREOF | ST Pharm Co., Ltd. (KR) | 2018-10-17 | — | — | EP | disclosed |
| WO-2017099424-A1 | NOVEL DIHYDROPYRANOPYRIMIDINONE DERIVATIVES, AND USE THEREOF | ST PHARM CO., LTD. (KR) | 2017-06-15 | — | — | WO | disclosed |
| EP-0920867-A1 | Pyrido[2,3-a]pyrazine derivatives as PDE-IV and TNF inhibitors | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-06-09 | — | — | EP | disclosed |
| EP-0355612-B1 | Furylthiazole derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1994-07-27 | — | — | EP | disclosed |
| US-4822805-A | ANTIINFLAMMATORY AGENTS, CARDIOTONIC AGENTS, ANTIPLATELET AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-04-18 | — | — | US | disclosed |
| EP-0257897-A1 | Imidazole compounds, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-03-02 | — | — | EP | disclosed |
| US-RE30456-E | ANTIFERTILITY AGENTS, ANTIINFLAMATORY AGENTS AND CENTRAL NERVOUS SYSTEM DEPRESSANTS | GRUPPO LEPETIT S.P.A. (IT) | 1980-12-23 | — | — | US | disclosed |
| US-RE30456-E | ANTIFERTILITY AGENTS, ANTIINFLAMATORY AGENTS AND CENTRAL NERVOUS SYSTEM DEPRESSANTS | GRUPPO LEPETIT S.P.A. (IT) | 1980-12-23 | — | — | US | disclosed |
| US-4075341-A | 2-Substituted phenyl-5-triazols [5,1-a] isoquinoline compounds | GRUPPO LEPETIT S.P.A. (IT) | 1978-02-21 | — | — | US | disclosed |
| US-4075341-A | 2-Substituted phenyl-5-triazols [5,1-a] isoquinoline compounds | GRUPPO LEPETIT S.P.A. (IT) | 1978-02-21 | — | — | US | disclosed |
| US-4007276-A | ANTIFERTILITY, ANTIINFLAMMATORY, ANALGESIC, CNS DEPRESSANT, MICROBIOCIDES | GRUPPO LEPETIT, S.P.A. (IT) | 1977-02-08 | — | — | US | disclosed |