Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | BLM | P54132 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | PARP1 | P09874 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | CES1 | P23141 | 3/20 | 0.46 |
| ▸ | CES2 | O00748 | 2/20 | 0.46 |
| ▸ | DAO | P14920 | 1/20 | 0.46 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL543877 | 0.85 | CES1 (0.55) | TDP1MAPTCYP2C19TSHRCYP3A4 | |
| SCHEMBL2880519 | 0.82 | MAPT (0.50) | TDP1MAPTCYP2C19TSHRCYP3A4 | |
| SCHEMBL7365656 | 0.82 | CYP2C19 (0.50) | TDP1MAPTCYP2C19TSHRCYP3A4 | |
| SCHEMBL3784819 | 0.80 | CES1 (0.50) | TDP1MAPTCYP2C19TSHRCYP3A4 | |
| SCHEMBL9678142 | 0.79 | CYP2C19 (0.52) | TDP1MAPTCYP2C19TSHRCYP3A4 | |
| SCHEMBL7778378 | 0.77 | ALDH1A1 (0.50) | TDP1MAPTPOLBGAAALDH1A1 | |
| SCHEMBL828587 | 0.76 | TPH1 (0.55) | TDP1MAPTCYP2C19TSHRCYP3A4 | |
| SCHEMBL3035866 | 0.76 | CES2 (0.50) | TDP1MAPTCYP2C19TSHRCYP3A4 | |
| SCHEMBL732449 | 0.75 | TDP1 (0.52) | TDP1MAPTCYP2C19TSHRCYP3A4 | |
| Hydrochloric Acid SCHEMBL27296270 | 0.74 | TPH1 (0.53) | TDP1MAPTCYP2C19TSHRCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2838531-B1 | INDOLIN-2-ONE DERIVATIVES AS PROTEIN KINASE INHIBITORS | ANNJI PHARM CO LTD (CN) | 2016-09-21 | — | — | EP | claimed |
| US-8946282-B2 | Indolin-2-one derivatives as protein kinase inhibitors | Annji Pharmaceutical Co., Ltd. (TW) | 2015-02-03 | — | — | US | claimed |
| US-20130281451-A1 | INDOLIN-2-ONE DERIVATIVES AS PROTEIN KINASE INHIBITORS | Annji Pharmaceutical Co., Ltd. (TW) | 2013-10-24 | — | — | US | claimed |
| EP-2838531-B1 | INDOLIN-2-ONE DERIVATIVES AS PROTEIN KINASE INHIBITORS | ANNJI PHARM CO LTD (CN) | 2016-09-21 | — | — | EP | disclosed |
| US-8946282-B2 | Indolin-2-one derivatives as protein kinase inhibitors | Annji Pharmaceutical Co., Ltd. (TW) | 2015-02-03 | — | — | US | disclosed |
| US-8946282-B2 | Indolin-2-one derivatives as protein kinase inhibitors | Annji Pharmaceutical Co., Ltd. (TW) | 2015-02-03 | — | — | US | disclosed |
| US-8703935-B2 | Method of producing a metal phthalocyanine compound, and method of producing a phthalocyanine compound and an analogue thereof | FUJIFILM CORPORATION (JP) | 2014-04-22 | — | — | US | disclosed |
| US-20130281451-A1 | INDOLIN-2-ONE DERIVATIVES AS PROTEIN KINASE INHIBITORS | Annji Pharmaceutical Co., Ltd. (TW) | 2013-10-24 | — | — | US | disclosed |
| US-20130012697-A1 | METHOD OF PRODUCING A METAL PHTHALOCYANINE COMPOUND, AND METHOD OF PRODUCING A PHTHALOCYANINE COMPOUND AND AN ANALOGUE THEREOF | FUJIFILM CORPORATION (JP) | 2013-01-10 | — | — | US | disclosed |
| US-8299240-B2 | Method of producing a metal phthalocyanine compound, and method of producing a phthalocyanine compound and an analogue thereof | FUJIFILM CORPORATION (JP) | 2012-10-30 | — | — | US | disclosed |
| EP-1940967-B1 | METHOD OF PRODUCING A METAL PHTHALOCYANINE COMPOUND, AND METHOD OF PRODUCING A PHTHALOCYANINE COMPOUND AND AN ANALOGUE THEREOF | FUJIFILM CORP (JP) | 2012-10-17 | — | — | EP | disclosed |
| US-20090247742-A1 | METHOD OF PRODUCING A METAL PHTHALOCYANINE COMPOUND, AND METHOD OF PRODUCING A PHTHALOCYANINE COMPOUND AND AN ANALOGUE THEREOF | FUJIFILM CORPORATION (JP) | 2009-10-01 | — | — | US | disclosed |
| EP-1984454-A1 | METHOD OF MANUFACTURING PHTHALOCYANINE COMPOUND | Fujifilm Corporation (JP) | 2008-10-29 | — | — | EP | disclosed |
| EP-1940967-A1 | METHOD OF PRODUCING A METAL PHTHALOCYANINE COMPOUND, AND METHOD OF PRODUCING A PHTHALOCYANINE COMPOUND AND AN ANALOGUE THEREOF | FUJIFILM Corporation (JP) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007086537-A1 | METHOD OF MANUFACTURING PHTHALOCYANINE COMPOUND | FUJIFILM CORPORATION (JP) | 2007-08-02 | — | — | WO | disclosed |
| WO-2007037039-A1 | METHOD OF PRODUCING A METAL PHTHALOCYANINE COMPOUND, AND METHOD OF PRODUCING A PHTHALOCYANINE COMPOUND AND AN ANALOGUE THEREOF | FUJIFILM CORPORATION (JP) | 2007-04-05 | — | — | WO | disclosed |
| US-4341776-A | BACTERICIDES | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 1982-07-27 | — | — | US | disclosed |
| US-4328224-A | ANTIBIOTICS | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 1982-05-04 | — | — | US | disclosed |
| US-4301161-A | BACTERICIDES | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 1981-11-17 | — | — | US | disclosed |
| US-4298605-A | ANTIBIOTICS, BACTERICIDES | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 1981-11-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130281451-A1 | INDOLIN-2-ONE DERIVATIVES AS PROTEIN KINASE INHIBITORS | ING2, CDK2, MAP3K20 | TDP1 649/4885MAPT 2360/4885CYP2C19 4519/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.