Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 5/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.44 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | METAP2 | P50579 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7363886 | 0.92 | KDM4E (0.44) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL7370274 | 0.89 | PDE4A (0.52) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL7365395 | 0.88 | PDE4A (0.61) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL7366174 | 0.85 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL7369736 | 0.84 | TSHR (0.45) | KDM4EKMT2AMEN1GAASMN1; SMN2 | |
| SCHEMBL7364707 | 0.84 | HPGD (0.52) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL7369403 | 0.84 | KDM4E (0.44) | PDE4AKDM4EGAASMN1; SMN2TSHR | |
| SCHEMBL7362649 | 0.84 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL7363855 | 0.83 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL7359750 | 0.81 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4DKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0612321-A1 | PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1994-08-31 | — | — | EP | disclosed |
| WO-1993007146-A1 | BENZO AND PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1993-04-15 | — | — | WO | disclosed |