Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7363886 | 0.92 | KDM4E (0.44) | TSHRMEN1KMT2AGAAKDM4E | |
| SCHEMBL7359750 | 0.87 | PDE4A (0.50) | TSHRKDM4EALDH1A1NPSR1CYP3A4 | |
| SCHEMBL7366365 | 0.86 | PDE4A (0.52) | TSHRMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL7367933 | 0.85 | ALDH1A1 (0.56) | TSHRMEN1KMT2AGAASMN1; SMN2 | |
| SCHEMBL7364396 | 0.84 | ALDH1A1 (0.52) | TSHRMEN1KMT2ASMN1; SMN2HPGD | |
| SCHEMBL7365735 | 0.84 | PDE4A (0.44) | TSHRMEN1KMT2AGAAKDM4E | |
| SCHEMBL7369732 | 0.82 | KDM4E (0.44) | TSHRKDM4ESMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL7363039 | 0.82 | PDE4A (0.47) | MEN1KMT2AGAAKDM4ESMN1; SMN2 | |
| SCHEMBL7370274 | 0.79 | PDE4A (0.52) | GAAKDM4EALDH1A1NPSR1CYP3A4 | |
| SCHEMBL7370600 | 0.79 | MEN1 (0.51) | MEN1KMT2AGAASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993007146-A1 | BENZO AND PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1993-04-15 | — | — | WO | disclosed |