Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7369736 | 0.92 | TSHR (0.45) | KDM4ESMN1; SMN2TSHRHPGDMEN1 | |
| SCHEMBL7365735 | 0.92 | PDE4A (0.44) | KDM4ETBXAS1SMN1; SMN2TSHRPDE4A | |
| SCHEMBL7359750 | 0.89 | PDE4A (0.50) | KDM4ETSHRPDE4APDE4BPDE4C | |
| SCHEMBL7366365 | 0.88 | PDE4A (0.52) | KDM4ETSHRPDE4APDE4BPDE4C | |
| SCHEMBL7365662 | 0.84 | HPGD (0.55) | KDM4ETBXAS1SMN1; SMN2TSHRPDE4A | |
| SCHEMBL7369732 | 0.84 | KDM4E (0.44) | KDM4ESMN1; SMN2TSHRHPGDALDH1A1 | |
| SCHEMBL8699836 | 0.84 | TBXAS1 (0.45) | KDM4ETBXAS1SMN1; SMN2TSHRPDE4A | |
| SCHEMBL7363039 | 0.83 | PDE4A (0.47) | KDM4ESMN1; SMN2PDE4APDE4BPDE4C | |
| SCHEMBL7370274 | 0.81 | PDE4A (0.52) | KDM4EPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7365395 | 0.80 | PDE4A (0.61) | KDM4EPDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0612321-A1 | PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1994-08-31 | — | — | EP | disclosed |
| WO-1993007146-A1 | BENZO AND PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1993-04-15 | — | — | WO | disclosed |