Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.38 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | IL1B | P01584 | 1/20 | 0.36 |
| ▸ | METAP2 | P50579 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7369732 | 0.92 | KDM4E (0.44) | KDM4EPOLBTSHRHSD17B10KAT2B | |
| SCHEMBL7363887 | 0.84 | KAT2B (0.52) | KDM4EPOLBTSHRHSD17B10KAT2B | |
| SCHEMBL7365735 | 0.84 | PDE4A (0.44) | KDM4ETSHRGAAMETAP2SMN1; SMN2 | |
| SCHEMBL7371143 | 0.84 | KDM4E (0.53) | KDM4EPOLBTSHRHSD17B10KAT2B | |
| SCHEMBL7363855 | 0.83 | PDE4A (0.47) | KDM4EPOLBHSD17B10MAPTL3MBTL1 | |
| SCHEMBL7370274 | 0.81 | PDE4A (0.52) | KDM4EMAPTL3MBTL1ALDH1A1GAA | |
| SCHEMBL7365395 | 0.80 | PDE4A (0.61) | KDM4EPOLBLMNAALDH1A1GAA | |
| SCHEMBL7370561 | 0.78 | L3MBTL1 (0.47) | POLBKAT2BMAPTL3MBTL1ALDH1A1 | |
| SCHEMBL7363886 | 0.78 | KDM4E (0.44) | KDM4EPOLBTSHRL3MBTL1HPGD | |
| SCHEMBL7363024 | 0.78 | KMT2A (0.50) | KDM4EMAPTL3MBTL1PSMD14LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0612321-A1 | PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1994-08-31 | — | — | EP | disclosed |
| WO-1993007146-A1 | BENZO AND PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1993-04-15 | — | — | WO | disclosed |