SCHEMBL7365863

SCHEMBL7365863

CC1(C)N(Cc2ccc(C#N)cc2)C(=O)N(Cc2ccc(C#N)cc2)C1(C)C

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 2/20 0.47
CA9 Q16790 2/20 0.47
CYP19A1 P11511 2/20 0.46
CYP2A6 P11509 1/20 0.46
CA2 P00918 1/20 0.44
PRMT5 O14744 5/20 0.44
WDR77 Q9BQA1 5/20 0.44
MDM2 Q00987 3/20 0.43
MAPT P10636 1/20 0.43
THRB P10828 1/20 0.43
CYP11B1 P15538 1/20 0.43
CYP11B2 P19099 1/20 0.43
LOXL2 Q9Y4K0 1/20 0.43
MEN1 O00255 1/20 0.43
CYP1A2 P05177 1/20 0.43
CYP2C9 P11712 1/20 0.43
TSHR P16473 1/20 0.43
KMT2A Q03164 1/20 0.43
TAS2R8 Q9NYW2 1/20 0.42
CYP2D6 P10635 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7364966 0.81 L3MBTL1 (0.47) CYP19A1MAPTCYP11B1CYP11B2KMT2A
SCHEMBL28555563 0.79 CA12 (0.44) CA12CA9CYP19A1CYP2A6CA2
SCHEMBL11643809 0.75 PRMT5 (0.54) CA12CA9CYP19A1CYP2A6PRMT5
SCHEMBL7436022 0.71 PRMT5 (0.55) CYP19A1CYP2A6PRMT5WDR77CYP11B1
SCHEMBL8122536 0.71 ALDH1A1 (0.53) PRMT5WDR77MAPT
SCHEMBL17140413 0.70 USP2 (0.49) CA12CA9CA2MEN1CYP1A2
SCHEMBL16627277 0.70 PRMT5 (0.46) CA12CA9CYP19A1CA2PRMT5
SCHEMBL8439250 0.70 CYP19A1 (0.45) CYP19A1MAPTTSHRKMT2A
SCHEMBL28572080 0.69 MGLL (0.69) CA12CA9CYP19A1CYP2A6CA2
SCHEMBL8440152 0.69 PRMT5 (0.52) CA12CA9CYP19A1CYP2A6CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5863914-A ADMINISTERING TO HUMAN N,N-DIMETHYLBENZENE OR N,N-DIMETHYLNAPHTHALENE-CYCLIC UREA DERIVATIVE TO TREAT A DISEASE-STATE CAUSED BY INHIBITION OF FACTOR XA MOHAN RAJU (US) 1999-01-26 US disclosed
US-5859005-A INHIBITORS OF THROMBIN AND FACTOR XA BERLEX LABORATORIES, INC. (US) 1999-01-12 US disclosed
EP-0848708-A1 N,N-DI(ARYLMETHYL)CYCLIC UREA DERIVATIVES AS ANTI-COAGULANTS BERLEX LABORATORIES, INC. (US) 1998-06-24 EP disclosed
US-5731308-A N,N-di(aryl) cyclic urea derivatives as anti-coagulants BERLEX LABORATORIES, INC. (US) 1998-03-24 US disclosed
US-5731311-A N,N-di(aryl) cyclic urea derivatives as anti-coagulants BERLEX LABORATORIES, INC. (US) 1998-03-24 US disclosed
US-5728697-A INHIBITORS OF FACTOR X BERLEX LABORATORIES, INC. (US) 1998-03-17 US disclosed
US-5726173-A ANTICOAGULANTS BERLEX LABORATORIES, INC. (US) 1998-03-10 US disclosed
US-5726198-A FOR INHIBITING COAGULATION ENZYMES BERLEX LABORATORIES, INC. (US) 1998-03-10 US disclosed
US-5612363-A FACTOR XA INHIBITORS BERLEX LABORATORIES, INC. (US) 1997-03-18 US disclosed
WO-1996038421-A1 N,N-DI(ARYLMETHYL)CYCLIC UREA DERIVATIVES AS ANTI-COAGULANTS BERLEX LABORATORIES, INC. (US) 1996-12-05 WO disclosed