Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.39 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 2/20 | 0.37 |
| ▸ | MAOB | P27338 | 2/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.37 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.37 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6134673 | 0.83 | MAPK14 (0.41) | KCNH2SPHK1 | |
| SCHEMBL7366397 | 0.70 | SPHK1 (0.58) | KCNH2RAB9ANPC1KDM4ESMN1; SMN2 | |
| SCHEMBL12420655 | 0.67 | NR4A1 (0.57) | PARP10KMT2AEGFRMAOAMAOB | |
| SCHEMBL7365257 | 0.66 | SPHK1 (0.50) | KCNH2RAB9ANPC1KDM4EKMT2A | |
| SCHEMBL7366434 | 0.65 | MBTPS1 (0.47) | KCNH2RAB9ANPC1HTR2CHTR2B | |
| SCHEMBL7371918 | 0.65 | ADAM17 (0.49) | KCNH2RAB9ANPC1PARP10MAOA | |
| SCHEMBL8190796 | 0.64 | SPHK1 (0.48) | KCNH2RAB9ANPC1KDM4ESMN1; SMN2 | |
| SCHEMBL7371853 | 0.63 | LTA4H (0.54) | RAB9ANPC1PARP10 | |
| SCHEMBL7403639 | 0.63 | NPC1 (0.46) | KCNH2RAB9ANPC1PARP10KDM4E | |
| Carbamic Acid SCHEMBL5481170 | 0.63 | KDM4E (0.65) | RAB9AHTR2CHTR2BPARP10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998054123-A1 | SUBSTITUTED PEPTIDYLAMINE CALCIUM CHANNEL BLOCKERS | WARNER-LAMBERT COMPANY (US) | 1998-12-03 | — | — | WO | claimed |
| WO-1998054123-A1 | SUBSTITUTED PEPTIDYLAMINE CALCIUM CHANNEL BLOCKERS | WARNER-LAMBERT COMPANY (US) | 1998-12-03 | — | — | WO | disclosed |