Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | AGER | Q15109 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | UNG | P13051 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | NEK2 | P51955 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | DHODH | Q02127 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7369369 | 0.89 | ALDH1A1 (0.51) | KDM4EALDH1A1MAPTCYP3A4ALOX15 | |
| SCHEMBL296670 | 0.79 | KDM4E (0.69) | KDM4EALDH1A1MAPTCYP3A4ALOX15 | |
| SCHEMBL7366851 | 0.79 | ALOX15 (0.56) | KDM4EALDH1A1MAPTCYP3A4ALOX15 | |
| SCHEMBL7366513 | 0.79 | MAPT (0.56) | KDM4EALDH1A1MAPTCYP3A4ALOX15 | |
| SCHEMBL7366799 | 0.79 | POLB (0.63) | KDM4EALDH1A1MAPTCYP3A4ALOX15 | |
| SCHEMBL9375327 | 0.78 | KDM4E (0.54) | KDM4EALDH1A1MAPTCYP3A4ALOX15 | |
| Hydrochloric Acid SCHEMBL7853761 | 0.78 | KDM4E (0.67) | KDM4EALDH1A1MAPTCYP3A4ALOX15 | |
| Oxalic Acid SCHEMBL31550428 | 0.76 | KDM4E (0.65) | KDM4EALDH1A1MAPTCYP3A4ALOX15 | |
| SCHEMBL7369163 | 0.76 | ALDH1A1 (0.54) | KDM4EALDH1A1MAPTCYP3A4ALOX15 | |
| SCHEMBL7370589 | 0.76 | ALDH1A1 (0.55) | KDM4EALDH1A1MAPTCYP3A4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5716954-A | ANTIINFLAMMATORY AGENT, ANTIHISTAMINES, IMMUNOSUPPRESSION,AUTOIMMUNE DISEASES | SYNTEX U.S.A. INC. (US) | 1998-02-10 | — | — | US | disclosed |
| EP-0612321-A1 | PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1994-08-31 | — | — | EP | disclosed |
| WO-1993007146-A1 | BENZO AND PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1993-04-15 | — | — | WO | disclosed |