Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.84 |
| ▸ | TSHR | P16473 | 1/20 | 0.84 |
| ▸ | FDPS | P14324 | 1/20 | 0.65 |
| ▸ | TTR | P02766 | 1/20 | 0.64 |
| ▸ | HPGD | P15428 | 2/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.63 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.63 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.63 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.63 |
| ▸ | ABAT | P80404 | 1/20 | 0.63 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.63 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21328335 | 0.96 | ALDH1A1 (0.85) | ALDH1A1TSHRFDPSTTRHPGD | |
| SCHEMBL1869030 | 0.92 | ALDH1A1 (0.84) | ALDH1A1TSHRFDPSTTRHPGD | |
| 3,4-Dimethoxybenzaldehyde SCHEMBL1330962 | 0.91 | ALDH1A1 (1.00) | ALDH1A1TSHRFDPSTTRHPGD | |
| 3,4-Dimethoxybenzaldehyde SCHEMBL29364994 | 0.91 | ALDH1A1 (1.00) | ALDH1A1TSHRFDPSTTRHPGD | |
| 3,4-Dimethoxybenzaldehyde SCHEMBL5308959 | 0.91 | ALDH1A1 (1.00) | ALDH1A1TSHRFDPSTTRHPGD | |
| 3,4-Dimethoxybenzaldehyde SCHEMBL25202 | 0.91 | ALDH1A1 (1.00) | ALDH1A1TSHRFDPSTTRHPGD | |
| 3,4-Dimethoxybenzaldehyde SCHEMBL29624454 | 0.89 | ALDH1A1 (0.96) | ALDH1A1TSHRFDPSTTRHPGD | |
| 3,4-Dimethoxybenzaldehyde SCHEMBL28205798 | 0.89 | ALDH1A1 (0.96) | ALDH1A1TSHRFDPSTTRHPGD | |
| SCHEMBL26927383 | 0.89 | ALDH1A1 (0.79) | ALDH1A1TSHRFDPSTTRHPGD | |
| SCHEMBL23697323 | 0.88 | ALDH1A1 (0.66) | ALDH1A1TSHRFDPSTTRHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190275027-A1 | Bis-Benzyl-Tetrahydroisoquinoline Derivatives As Therapeutics For Filovirus | SOUTHWEST RESEARCH INSTITUTE | 2019-09-12 | — | — | US | disclosed |
| US-20190275027-A1 | Bis-Benzyl-Tetrahydroisoquinoline Derivatives As Therapeutics For Filovirus | SOUTHWEST RESEARCH INSTITUTE | 2019-09-12 | — | — | US | disclosed |
| US-5459145-A | Calcium independent camp phosphodiesterase inhibitor antidepressant | PFIZER INC. (US) | 1995-10-17 | — | — | US | disclosed |
| US-5294730-A | A-Amino-4-alkoxy-3-polycycloalkyloxybenzyl cyanide derivatives | PFIZER INC. (US) | 1994-03-15 | — | — | US | disclosed |
| EP-0247725-B1 | Calcium independent camp phosphodiestrerase inhibitor antidepressant | PFIZER (US) | 1994-03-02 | — | — | EP | disclosed |
| US-5196426-A | CALCIUM INDEPENDENT C AMP PHOSPHODIESTERASE INHIBITOR ANTIDEPRESSANT | PFIZER INC. (US) | 1993-03-23 | — | — | US | disclosed |
| CN-1018827-B | CALCIUM INDEPENDENT CAMP PHOSPHODIESTERASE INHIBITOR ANTIDEPRESSANT | PFIZER (US) | 1992-10-28 | — | — | CN | disclosed |
| US-5128358-A | Aryl substituted nitrogen heterocyclic antidepressants | PFIZER INC. (US) | 1992-07-07 | — | — | US | disclosed |
| EP-0247725-A2 | Calcium independent camp phosphodiestrerase inhibitor antidepressant | PFIZER INC. (US) | 1987-12-02 | — | — | EP | disclosed |
| CN-87103225-A | Antidepressant noncalcium Cyclic Adenosine Monophosphate (CAMP) phosphodiesterase inhibitor | — | 1987-11-11 | — | — | CN | disclosed |
| WO-1987006576-A1 | CALCIUM INDEPENDENT CAMP PHOSPHODIESTERASE INHIBITOR ANTIDEPRESSANT | PFIZER INC. (US) | 1987-11-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190275027-A1 | Bis-Benzyl-Tetrahydroisoquinoline Derivatives As Therapeutics For Filovirus | TREH, TTN, TSN | ALDH1A1 2748/4885TSHR 1544/4885FDPS 1971/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.