Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.66 |
| ▸ | MEN1 | O00255 | 3/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | KDR | P35968 | 2/20 | 0.52 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | F10 | P00742 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7374239 | 0.85 | KMT2A (0.60) | KMT2AMEN1TDP1HTTKDR | |
| SCHEMBL7374880 | 0.83 | MEN1 (0.63) | KMT2AMEN1TDP1ALDH1A1F10 | |
| SCHEMBL6457966 | 0.80 | TDP1 (0.56) | KMT2AMEN1TDP1PKMMAPK1 | |
| SCHEMBL7374241 | 0.80 | TDP1 (0.59) | KMT2AMEN1TDP1PKMMAPK1 | |
| SCHEMBL5753134 | 0.80 | MAPK1 (0.57) | KMT2AMEN1TDP1MAPK1HTT | |
| SCHEMBL7364675 | 0.79 | TDP1 (0.65) | KMT2AMEN1TDP1PKMMAPK1 | |
| SCHEMBL7373168 | 0.78 | MAPK8 (0.73) | KMT2AMEN1TDP1ALDH1A1POLB | |
| SCHEMBL861902 | 0.78 | TDP1 (0.71) | KMT2AMEN1TDP1ALDH1A1POLB | |
| SCHEMBL2332693 | 0.78 | ALDH1A1 (0.61) | TDP1ALDH1A1POLBGAARAB9A | |
| SCHEMBL7313745 | 0.78 | KMT2A (0.54) | KMT2AMEN1TDP1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380218-B1 | FOR THERAPY OF RESPIRATORY, ALLERGIC, AND INFLAMMATORY DISORDERS COMPRISING ASTHMA, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ACUTE RESPIRATORY DISEASE SYNDROME, PULMONARY HYPERSENSITIVITY, AND ALLERGIC RHINITIS IN A MAMMAL | PFIZER INC | 2002-04-30 | — | — | US | disclosed |
| EP-0971894-A1 | NICOTINAMIDE DERIVATIVES | Pfizer Products Inc. (US) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998045268-A1 | NICOTINAMIDE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 1998-10-15 | — | — | WO | disclosed |