Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.48 |
| ▸ | XDH | P47989 | 1/20 | 0.47 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.47 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.47 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.46 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.46 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7674124 | 0.89 | ALDH1A1 (0.58) | ALDH1A1POLBGAARAB9ATDP1 | |
| SCHEMBL7364681 | 0.87 | RAB9A (0.72) | ALDH1A1POLBGAARAB9ATDP1 | |
| SCHEMBL2779334 | 0.84 | RAB9A (0.76) | ALDH1A1POLBGAARAB9ATDP1 | |
| SCHEMBL10971064 | 0.83 | ALDH1A1 (0.72) | ALDH1A1POLBGAATDP1MAPK8 | |
| SCHEMBL7367990 | 0.83 | RAB9A (0.52) | ALDH1A1POLBGAARAB9ATDP1 | |
| SCHEMBL861902 | 0.83 | TDP1 (0.71) | ALDH1A1POLBGAARAB9ATDP1 | |
| SCHEMBL7313745 | 0.83 | KMT2A (0.54) | ALDH1A1POLBGAATDP1PTGER4 | |
| SCHEMBL10970875 | 0.83 | TDP1 (0.52) | ALDH1A1POLBGAARAB9ATDP1 | |
| SCHEMBL7374241 | 0.83 | TDP1 (0.59) | ALDH1A1POLBGAARAB9ATDP1 | |
| SCHEMBL8476272 | 0.83 | ALDH1A1 (0.55) | ALDH1A1POLBGAARAB9ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8309734-B2 | Substituted pyridines as GPBAR1 agonists | HOFFMANN-LA ROCHE INC. (US) | 2012-11-13 | — | — | US | disclosed |
| EP-2356094-A1 | NOVEL PHENYL AMIDE OR PYRIDIL AMIDE DERIVATIVES AND THEIR USE AS GPBAR1 AGONISTS | F. Hoffmann-La Roche AG (CH) | 2011-08-17 | — | — | EP | disclosed |
| WO-2010059838-A2 | PDE4 INHIBITORS SELECTIVE FOR THE LONG FORM OF PDE4 FOR TREATING INFLAMMATION AND AVOIDING SIDE EFFECTS | DECODE GENETICS EHF (IS) | 2010-05-27 | — | — | WO | disclosed |
| WO-2010059838-A2 | PDE4 INHIBITORS SELECTIVE FOR THE LONG FORM OF PDE4 FOR TREATING INFLAMMATION AND AVOIDING SIDE EFFECTS | DECODE GENETICS EHF (IS) | 2010-05-27 | — | — | WO | disclosed |
| WO-2010049302-A1 | NOVEL PHENYL AMIDE OR PYRIDIL AMIDE DERIVATIVES AND THEIR USE AS GPBAR1 AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-05-06 | — | — | WO | disclosed |
| US-20100105906-A1 | NOVEL PHENYL AMIDE OR PYRIDYL AMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG, A SWISS COMPANY (CH) | 2010-04-29 | — | — | US | disclosed |
| EP-1963275-A2 | P2X7 RECEPTOR ANTAGONISTS AND USES THEREOF | Abbott Laboratories (US) | 2008-09-03 | — | — | EP | disclosed |
| US-20070259920-A1 | P2X7, receptor antagonists and uses thereof | ABBOTT LABORATORIES | 2007-11-08 | — | — | US | disclosed |
| WO-2007056091-A2 | 2-PHENYL-2H-PYRAZ0LE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS AND USES THEREOF | ABBOTT LABORATORIES (US) | 2007-05-18 | — | — | WO | disclosed |
| US-6380218-B1 | FOR THERAPY OF RESPIRATORY, ALLERGIC, AND INFLAMMATORY DISORDERS COMPRISING ASTHMA, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ACUTE RESPIRATORY DISEASE SYNDROME, PULMONARY HYPERSENSITIVITY, AND ALLERGIC RHINITIS IN A MAMMAL | PFIZER INC | 2002-04-30 | — | — | US | disclosed |
| EP-0971894-A1 | NICOTINAMIDE DERIVATIVES | Pfizer Products Inc. (US) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998045268-A1 | NICOTINAMIDE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 1998-10-15 | — | — | WO | disclosed |
| EP-0053011-B1 | NEW HERBICIDAL NICOTINAMIDE DERIVATIVES | MAY & BAKER LIMITED (GB) | 1985-04-03 | — | — | EP | disclosed |
| EP-0053011-A1 | New herbicidal nicotinamide derivatives | MAY & BAKER LIMITED (GB) | 1982-06-02 | — | — | EP | disclosed |
| US-4327218-A | HERBICIDES | STAUFFER CHEMICAL COMPANY (US) | 1982-04-27 | — | — | US | disclosed |
| US-4270946-A | N-Aryl,2-phenoxy nicotinamide compounds and the herbicidal use thereof | STAUFFER CHEMICAL COMPANY (US) | 1981-06-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100105906-A1 | NOVEL PHENYL AMIDE OR PYRIDYL AMIDE DERIVATIVES | GPBAR1, GPR119, GLP1R | ALDH1A1 341/4885POLB 2406/4885GAA 1013/4885 |
| US-20070259920-A1 | P2X7, receptor antagonists and uses thereof | P2RX7, P2RX1, P2RX3 | ALDH1A1 2161/4885POLB 4437/4885GAA 3104/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.