Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7373289 | 0.84 | PDE10A (0.46) | TDP1SMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL4828049 | 0.83 | L3MBTL1 (0.49) | TDP1L3MBTL1SMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL4828046 | 0.80 | GAA (0.55) | TDP1L3MBTL1SMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL8560540 | 0.79 | GAA (0.62) | TDP1L3MBTL1ALDH1A1RAB9ATSHR | |
| SCHEMBL7369514 | 0.78 | CARM1 (0.52) | TDP1L3MBTL1SMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL7373185 | 0.78 | TDP1 (0.44) | TDP1L3MBTL1SMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL7369632 | 0.77 | PTGS2 (0.48) | TDP1L3MBTL1SMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL7365621 | 0.77 | NPC1 (0.58) | TDP1L3MBTL1SMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL20831533 | 0.77 | TDP1 (0.72) | TDP1L3MBTL1ALDH1A1LMNATSHR | |
| SCHEMBL7375134 | 0.77 | TSHR (0.71) | TDP1L3MBTL1SMN1; SMN2ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380218-B1 | FOR THERAPY OF RESPIRATORY, ALLERGIC, AND INFLAMMATORY DISORDERS COMPRISING ASTHMA, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ACUTE RESPIRATORY DISEASE SYNDROME, PULMONARY HYPERSENSITIVITY, AND ALLERGIC RHINITIS IN A MAMMAL | PFIZER INC | 2002-04-30 | — | — | US | disclosed |
| EP-0971894-A1 | NICOTINAMIDE DERIVATIVES | Pfizer Products Inc. (US) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998045268-A1 | NICOTINAMIDE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 1998-10-15 | — | — | WO | disclosed |