Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 6/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | DRD1 | P21728 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7372384 | 0.87 | TDP1 (0.44) | TDP1ALDH1A1RAB9ALMNADRD1 | |
| SCHEMBL4828049 | 0.80 | L3MBTL1 (0.49) | TDP1L3MBTL1SMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL7366318 | 0.78 | L3MBTL1 (0.45) | L3MBTL1SMN1; SMN2NPC1ALDH1A1RAB9A | |
| SCHEMBL8560540 | 0.78 | GAA (0.62) | TDP1L3MBTL1ALDH1A1RAB9ATSHR | |
| SCHEMBL7369514 | 0.78 | CARM1 (0.52) | TDP1L3MBTL1SMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL7366446 | 0.77 | TDP1 (0.44) | PTGS2TDP1L3MBTL1SMN1; SMN2NPC1 | |
| SCHEMBL20831533 | 0.76 | TDP1 (0.72) | TDP1L3MBTL1ALDH1A1LMNATSHR | |
| SCHEMBL7684125 | 0.76 | LMNA (0.62) | TDP1L3MBTL1SMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL7375134 | 0.76 | TSHR (0.71) | TDP1L3MBTL1SMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL7370504 | 0.76 | MAPK8 (0.50) | SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380218-B1 | FOR THERAPY OF RESPIRATORY, ALLERGIC, AND INFLAMMATORY DISORDERS COMPRISING ASTHMA, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ACUTE RESPIRATORY DISEASE SYNDROME, PULMONARY HYPERSENSITIVITY, AND ALLERGIC RHINITIS IN A MAMMAL | PFIZER INC | 2002-04-30 | — | — | US | disclosed |
| EP-0971894-A1 | NICOTINAMIDE DERIVATIVES | Pfizer Products Inc. (US) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998045268-A1 | NICOTINAMIDE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 1998-10-15 | — | — | WO | disclosed |