Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 15/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 15/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 15/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 15/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 15/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 15/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | REN | P00797 | 1/20 | 0.37 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5967082 | 0.88 | SMN1; SMN2 (0.47) | HTTSMN1; SMN2L3MBTL1CYP2D6CYP2C9 | |
| SCHEMBL5967334 | 0.86 | SMN1; SMN2 (0.49) | HTTSMN1; SMN2L3MBTL1CYP2D6CYP2C9 | |
| SCHEMBL6446002 | 0.86 | SMN1; SMN2 (0.49) | HTTSMN1; SMN2L3MBTL1CYP2D6CYP2C9 | |
| SCHEMBL7369161 | 0.86 | LMNA (0.45) | HTTSMN1; SMN2L3MBTL1CYP2D6CYP2C9 | |
| SCHEMBL7361914 | 0.85 | HTT (0.43) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7440531 | 0.84 | REN (0.45) | HTTSMN1; SMN2L3MBTL1REN | |
| SCHEMBL5966953 | 0.82 | PSEN1 (0.52) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5966981 | 0.81 | SMN1; SMN2 (0.49) | HTTSMN1; SMN2L3MBTL1CYP2D6CYP2C9 | |
| SCHEMBL5966841 | 0.80 | ALDH1A1 (0.49) | HTTSMN1; SMN2L3MBTL1CYP2D6CYP2C9 | |
| SCHEMBL5966879 | 0.78 | SMN1; SMN2 (0.48) | HTTSMN1; SMN2L3MBTL1CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0942924-A2 | METHODS AND COMPOUNDS FOR INHIBITING $g(b)-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS | Elan Pharmaceuticals, Inc. (US) | 1999-09-22 | — | — | EP | claimed |
| WO-1998022494-A9 | METHODS AND COMPOUNDS FOR INHIBITING β-AMYLOID PEPTIDE RELEASE AND/OR SYNTHESIS | — | 1998-08-20 | — | — | WO | claimed |
| WO-1998022494-A2 | METHODS AND COMPOUNDS FOR INHIBITING β-AMYLOID PEPTIDE RELEASE AND/OR SYNTHESIS | ELAN PHARMACEUTICALS, INC. (US) | 1998-05-28 | — | — | WO | claimed |
| EP-0942924-A2 | METHODS AND COMPOUNDS FOR INHIBITING $g(b)-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS | Elan Pharmaceuticals, Inc. (US) | 1999-09-22 | — | — | EP | disclosed |
| WO-1998022494-A9 | METHODS AND COMPOUNDS FOR INHIBITING β-AMYLOID PEPTIDE RELEASE AND/OR SYNTHESIS | — | 1998-08-20 | — | — | WO | disclosed |
| WO-1998022494-A2 | METHODS AND COMPOUNDS FOR INHIBITING β-AMYLOID PEPTIDE RELEASE AND/OR SYNTHESIS | ELAN PHARMACEUTICALS, INC. (US) | 1998-05-28 | — | — | WO | disclosed |