Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 4/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26258912 | 0.80 | POLB (0.76) | POLBKMT2AALDH1A1KDM4ETRPV4 | |
| SCHEMBL30343311 | 0.73 | POLB (0.76) | POLBKMT2AALDH1A1KDM4ECYP2C9 | |
| SCHEMBL29004530 | 0.73 | POLB (0.76) | POLBKMT2AALDH1A1KDM4ECYP2C9 | |
| SCHEMBL18177873 | 0.72 | KMT2A (1.00) | POLBKMT2AALDH1A1KDM4EMEN1 | |
| SCHEMBL3146247 | 0.70 | KDM4E (0.55) | POLBKMT2AALDH1A1KDM4ETRPV4 | |
| SCHEMBL2818868 | 0.70 | ALDH1A1 (0.58) | POLBKMT2AALDH1A1TRPV4CYP3A4 | |
| SCHEMBL7131206 | 0.69 | KDM4E (0.78) | POLBALDH1A1KDM4ETRPV4MAPT | |
| SCHEMBL2836224 | 0.69 | TSHR (0.72) | ALDH1A1KDM4EGAAL3MBTL1TSHR | |
| SCHEMBL6494527 | 0.69 | MAPT (0.64) | POLBKMT2AALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL25617500 | 0.69 | ALDH1A1 (0.60) | POLBKMT2AALDH1A1TRPV4CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999026932-A1 | BY AMIDINO GROUP SUBSTITUTED HETEROCYCLIC DERIVATIVES AND THEIR USE AS ANTICOAGULANTS | AXYS PHARMACEUTICALS, INC. (US) | 1999-06-03 | — | — | WO | disclosed |