Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 3/20 | 0.49 |
| ▸ | HTR2B | P41595 | 3/20 | 0.49 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.46 |
| ▸ | OXTR | P30559 | 3/20 | 0.44 |
| ▸ | SRD5A1 | P18405 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | PRKDC | P78527 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8742792 | 1.00 | HTR2C (0.49) | HTR2CHTR2BNOTUMOXTRSRD5A1 | |
| SCHEMBL7342239 | 1.00 | HTR2C (0.49) | HTR2CHTR2BNOTUMOXTRSRD5A1 | |
| SCHEMBL16589999 | 0.82 | SRD5A1 (0.51) | NOTUMSRD5A1 | |
| SCHEMBL7340995 | 0.80 | NOTUM (0.49) | HTR2BNOTUMSRD5A1HSD17B10DRD2 | |
| SCHEMBL7378144 | 0.80 | NOTUM (0.49) | HTR2BNOTUMSRD5A1HSD17B10DRD2 | |
| SCHEMBL16587000 | 0.80 | NOTUM (0.49) | NOTUMSRD5A1HTR6PDE4B | |
| SCHEMBL7372067 | 0.80 | NOTUM (0.49) | HTR2BNOTUMSRD5A1HSD17B10DRD2 | |
| SCHEMBL7368233 | 0.78 | MAOB (0.49) | NOTUMOXTR | |
| SCHEMBL3503762 | 0.78 | MAOB (0.49) | NOTUMOXTR | |
| SCHEMBL3381033 | 0.76 | OXTR (0.52) | HTR2CHTR2BOXTRHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0699680-B1 | Oxazoloquinolinone derivatives, their preparation and their use in therapy | SANOFI SYNTHELABO (FR) | 2000-03-08 | — | — | EP | disclosed |
| US-5641785-A | ANTIDEPRESSANTS, NERVOUS SYSTEM DISORDERS | SYNTHELABO (FR) | 1997-06-24 | — | — | US | disclosed |
| EP-0699680-A1 | Oxazoloquinolinone derivatives, their preparation and their use in therapy | SYNTHELABO (FR) | 1996-03-06 | — | — | EP | disclosed |