Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.47 |
| ▸ | HAO1 | Q9UJM8 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4733431 | 0.85 | BACE1 (0.44) | HAO1RAB9AGRM4NAPRT | |
| SCHEMBL6460814 | 0.84 | CARM1 (0.52) | RAB9ATDP1KMT2APDE10AALDH1A1 | |
| SCHEMBL7366258 | 0.84 | L3MBTL1 (0.52) | SLC22A12RAB9ATDP1KMT2AALDH1A1 | |
| SCHEMBL2336921 | 0.81 | RAB9A (0.54) | RAB9ATDP1KMT2APDE10AALDH1A1 | |
| SCHEMBL851191 | 0.79 | TDP1 (0.52) | RAB9ATDP1KMT2APDE10AALDH1A1 | |
| SCHEMBL5362007 | 0.79 | HCRTR1 (0.49) | HAO1TDP1ALDH1A1 | |
| SCHEMBL2779361 | 0.77 | KMT2A (0.65) | RAB9ATDP1KMT2APDE10AALDH1A1 | |
| SCHEMBL4734047 | 0.77 | BACE1 (0.43) | SLC22A12HAO1RAB9AGRM4 | |
| SCHEMBL7313745 | 0.77 | KMT2A (0.54) | TDP1KMT2AALDH1A1NAPRT | |
| SCHEMBL7363608 | 0.76 | KMT2A (0.53) | RAB9ATDP1KMT2APDE10AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380218-B1 | FOR THERAPY OF RESPIRATORY, ALLERGIC, AND INFLAMMATORY DISORDERS COMPRISING ASTHMA, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ACUTE RESPIRATORY DISEASE SYNDROME, PULMONARY HYPERSENSITIVITY, AND ALLERGIC RHINITIS IN A MAMMAL | PFIZER INC | 2002-04-30 | — | — | US | disclosed |
| EP-0971894-A1 | NICOTINAMIDE DERIVATIVES | Pfizer Products Inc. (US) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998045268-A1 | NICOTINAMIDE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 1998-10-15 | — | — | WO | disclosed |