SCHEMBL7367269

SCHEMBL7367269

CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NCCC(c1ccccc1O)P(=O)(O)O

nearest known ligand 0.51

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
MMP1 P03956 19/20 0.51
MMP2 P08253 8/20 0.51
MMP3 P08254 7/20 0.51
MMP8 P22894 4/20 0.48
MMP9 P14780 3/20 0.48
MMP7 P09237 3/20 0.48
FCER2 P06734 1/20 0.48
ADAM17 P78536 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6257513 0.82 MMP1 (0.58) MMP1MMP2MMP3MMP8MMP9
SCHEMBL7364027 0.78 MME (0.56) MMP1MMP2MMP3
SCHEMBL9351722 0.78 LTA4H (0.36)
SCHEMBL7367573 0.76 MMP1 (0.67) MMP1MMP2MMP3MMP8MMP9
SCHEMBL6418666 0.76 MMP1 (0.52) MMP1MMP2MMP3MMP8MMP9
SCHEMBL6418679 0.76 MMP1 (0.52) MMP1MMP2MMP3MMP8MMP9
SCHEMBL7589289 0.76 MMP1 (0.64) MMP1MMP2MMP3MMP8MMP9
SCHEMBL13986872 0.76 MMP1 (0.63) MMP1MMP2MMP3MMP8MMP9
SCHEMBL5886644 0.76 MMP1 (0.63) MMP1MMP2MMP3MMP8MMP9
SCHEMBL6412335 0.75 MMP1 (0.56) MMP1MMP2MMP3MMP8MMP9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1063991-A1 STATIN-MATRIX METALLOPROTEINASE INHIBITOR COMBINATIONS WARNER-LAMBERT COMPANY LLC (US) 2001-01-03 EP disclosed
EP-1047450-A1 ACE INHIBITOR-MMP INHIBITOR COMBINATIONS WARNER-LAMBERT COMPANY (US) 2000-11-02 EP disclosed
EP-1028716-A1 METHOD FOR TREATING AND PREVENTING HEART FAILURE AND VENTRICULAR DILATATION WARNER-LAMBERT COMPANY (US) 2000-08-23 EP disclosed
EP-0946166-A1 USE OF MATRIX METALLOPROTEINASE INHIBITORS FOR TREATING NEUROLOGICAL DISORDERS AND PROMOTING WOUND HEALING WARNER-LAMBERT COMPANY (US) 1999-10-06 EP disclosed
WO-1999047138-A1 STATIN-MATRIX METALLOPROTEINASE INHIBITOR COMBINATIONS WARNER-LAMBERT COMPANY (US) 1999-09-23 WO disclosed
WO-1999032150-A1 ACE INHIBITOR-MMP INHIBITOR COMBINATIONS WARNER-LAMBERT COMPANY (US) 1999-07-01 WO disclosed
WO-1998026773-A1 USE OF MATRIX METALLOPROTEINASE INHIBITORS FOR TREATING NEUROLOGICAL DISORDERS AND PROMOTING WOUND HEALING WARNER-LAMBERT COMPANY (US) 1998-06-25 WO disclosed
WO-1998025597-A2 METHOD FOR TREATING AND PREVENTING HEART FAILURE AND VENTRICULAR DILATATION WARNER-LAMBERT COMPANY (US) 1998-06-18 WO disclosed