Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.54 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | BCHE | P06276 | 2/20 | 0.51 |
| ▸ | ACHE | P22303 | 2/20 | 0.51 |
| ▸ | PDE5A | O76074 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7334095 | 0.82 | PDE4D (0.72) | KMT2AMEN1PDE4BPDE5A | |
| SCHEMBL7397257 | 0.82 | KMT2A (0.56) | KMT2AMEN1MAPTSMN1; SMN2HDAC1 | |
| SCHEMBL8188616 | 0.81 | PDE4D (0.63) | KMT2AMEN1MAPTSMN1; SMN2LMNA | |
| SCHEMBL7735233 | 0.80 | PDE5A (0.60) | KMT2AMEN1MAPTSMN1; SMN2LMNA | |
| SCHEMBL8189434 | 0.79 | MEN1 (0.67) | KMT2AMEN1MAPTSMN1; SMN2POLB | |
| SCHEMBL9272449 | 0.78 | ALDH1A1 (0.57) | KMT2AMEN1MAPTSMN1; SMN2LMNA | |
| SCHEMBL1157335 | 0.78 | CYP19A1 (0.61) | KMT2AMEN1MAPTSMN1; SMN2LMNA | |
| SCHEMBL16056331 | 0.77 | KMT2A (0.53) | KMT2AMEN1MAPTSMN1; SMN2HDAC1 | |
| SCHEMBL3543472 | 0.77 | PDE4A (0.56) | SMN1; SMN2PDE4B | |
| SCHEMBL7735278 | 0.77 | PDE4D (0.53) | KMT2AMAPTSMN1; SMN2LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0538384-A4 | OXAMIDES | SMITHKLINE BEECHAM CORP (US) | 1995-04-12 | — | — | EP | disclosed |
| US-5393788-A | Phenylalkyl oxamides | SMITHKLINE BEECHAM CORPORATION (US) | 1995-02-28 | — | — | US | disclosed |
| EP-0538384-A1 | OXAMIDES | SMITHKLINE BEECHAM CORPORATION (US) | 1993-04-28 | — | — | EP | disclosed |
| WO-1992000968-A1 | OXAMIDES | SMITHKLINE BEECHAM CORPORATION (US) | 1992-01-23 | — | — | WO | disclosed |