Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.47 |
| ▸ | PTGES | O14684 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7397484 | 0.84 | PDE4A (0.54) | KMT2AMEN1LMNAPOLBKDM4E | |
| SCHEMBL9272449 | 0.83 | ALDH1A1 (0.57) | KMT2AMAPTMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL9272958 | 0.82 | HDAC1 (0.56) | KMT2AMAPTMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL7367293 | 0.82 | EPHX2 (0.55) | KMT2AMAPTMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL1157335 | 0.79 | CYP19A1 (0.61) | KMT2AMAPTMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL7365073 | 0.79 | MEN1 (0.60) | KMT2AMAPTMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL16056331 | 0.79 | KMT2A (0.53) | KMT2AMAPTMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL7363656 | 0.79 | KCNH2 (0.47) | KMT2AMAPTMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL5704500 | 0.78 | CYP19A1 (0.62) | KMT2AMAPTMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL5822951 | 0.77 | PDE4A (0.63) | KMT2AMAPTMEN1SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0538384-A4 | OXAMIDES | SMITHKLINE BEECHAM CORP (US) | 1995-04-12 | — | — | EP | disclosed |
| US-5393788-A | Phenylalkyl oxamides | SMITHKLINE BEECHAM CORPORATION (US) | 1995-02-28 | — | — | US | disclosed |
| EP-0538384-A1 | OXAMIDES | SMITHKLINE BEECHAM CORPORATION (US) | 1993-04-28 | — | — | EP | disclosed |
| WO-1992000968-A1 | OXAMIDES | SMITHKLINE BEECHAM CORPORATION (US) | 1992-01-23 | — | — | WO | disclosed |