Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.53 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.48 |
| ▸ | PDE4A | P27815 | 1/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | BCL9 | O00512 | 1/20 | 0.47 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | PDE5A | O76074 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9523677 | 0.88 | KMT2A (0.60) | KMT2ABCL9CTNNB1ALDH1A1SMN1; SMN2 | |
| SCHEMBL7326412 | 0.81 | HDAC1 (0.58) | KMT2APDE4BPDE4APDE4CPDE4D | |
| SCHEMBL9272449 | 0.79 | ALDH1A1 (0.57) | KMT2APDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7397257 | 0.79 | KMT2A (0.56) | KMT2APDE4BALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL7363656 | 0.78 | KCNH2 (0.47) | KMT2APDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7420231 | 0.78 | HDAC1 (0.53) | KMT2APDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7335293 | 0.77 | PDE4A (0.58) | KMT2APDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7324348 | 0.77 | PDE4B (0.56) | KMT2APDE4BPDE4APDE4CPDE4D | |
| SCHEMBL8157358 | 0.77 | HDAC1 (0.56) | KMT2APDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7367293 | 0.77 | EPHX2 (0.55) | KMT2APDE4BALDH1A1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11306097-B2 | Activation of carbonyl beta-carbons for chemical transformations | NANYANG TECHNOLOGICAL UNIVERSITY (SG) | 2022-04-19 | — | — | US | disclosed |
| US-11306097-B2 | Activation of carbonyl beta-carbons for chemical transformations | NANYANG TECHNOLOGICAL UNIVERSITY (SG) | 2022-04-19 | — | — | US | disclosed |
| US-20190337955-A1 | ACTIVATION OF CARBONYL BETA-CARBONS FOR CHEMICAL TRANSFORMATIONS | UNIV NANYANG TECH (SG) | 2019-11-07 | — | — | US | disclosed |
| US-20190337955-A1 | ACTIVATION OF CARBONYL BETA-CARBONS FOR CHEMICAL TRANSFORMATIONS | UNIV NANYANG TECH (SG) | 2019-11-07 | — | — | US | disclosed |
| US-20160039827-A1 | ACTIVATION OF CARBONYL BETA-CARBONS FOR CHEMICAL TRANSFORMATIONS | NANYANG TECHNOLOGICAL UNIVERSITY (SG) | 2016-02-11 | — | — | US | disclosed |
| US-20160039827-A1 | ACTIVATION OF CARBONYL BETA-CARBONS FOR CHEMICAL TRANSFORMATIONS | NANYANG TECHNOLOGICAL UNIVERSITY (SG) | 2016-02-11 | — | — | US | disclosed |
| US-20160039827-A1 | ACTIVATION OF CARBONYL BETA-CARBONS FOR CHEMICAL TRANSFORMATIONS | NANYANG TECHNOLOGICAL UNIVERSITY (SG) | 2016-02-11 | — | — | US | disclosed |
| WO-2014142755-A1 | ACTIVATION OF CARBONYL β-CARBONS FOR CHEMICAL TRANSFORMATIONS | NANYANG TECHNOLOGICAL UNIVERSITY (SG) | 2014-09-18 | — | — | WO | disclosed |
| WO-2014142755-A1 | ACTIVATION OF CARBONYL β-CARBONS FOR CHEMICAL TRANSFORMATIONS | NANYANG TECHNOLOGICAL UNIVERSITY (SG) | 2014-09-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160039827-A1 | ACTIVATION OF CARBONYL BETA-CARBONS FOR CHEMICAL TRANSFORMATIONS | CBR1, CBR3, CAT | KMT2A 3146/4885PDE4B 1513/4885PDE4A 1813/4885 |
| US-20190337955-A1 | ACTIVATION OF CARBONYL BETA-CARBONS FOR CHEMICAL TRANSFORMATIONS | CBR1, CBR3, CAT | KMT2A 3146/4885PDE4B 1513/4885PDE4A 1813/4885 |
| US-11306097-B2 | Activation of carbonyl beta-carbons for chemical transformations | CBR1, CBR3, CAT | KMT2A 3146/4885PDE4B 1513/4885PDE4A 1813/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.