Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 1/20 | 0.50 |
| ▸ | CNR1 | P21554 | 2/20 | 0.49 |
| ▸ | CNR2 | P34972 | 2/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.48 |
| ▸ | FNTA | P49354 | 1/20 | 0.45 |
| ▸ | FNTB | P49356 | 1/20 | 0.45 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.45 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9040019 | 0.84 | MEN1 (0.49) | CYP19A1FNTAFNTBPGGT1BPIN1 | |
| SCHEMBL3287871 | 0.83 | ALDH1A1 (0.44) | CYP19A1PIN1ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL10955865 | 0.82 | KDM4E (0.53) | ARCYP19A1FNTAFNTBPGGT1B | |
| SCHEMBL9038839 | 0.82 | RAB9A (0.59) | ARCYP19A1FNTAFNTBPGGT1B | |
| SCHEMBL3293477 | 0.81 | ALDH1A1 (0.55) | PIN1ALDH1A1SMN1; SMN2KMT2AMAPT | |
| SCHEMBL13333183 | 0.80 | ALDH1A1 (0.41) | CYP19A1FNTAFNTBPGGT1BPIN1 | |
| SCHEMBL3167158 | 0.79 | F10 (0.42) | CYP19A1ALDH1A1SMN1; SMN2KMT2AMEN1 | |
| Methyl Alcohol SCHEMBL11374946 | 0.77 | MEN1 (0.55) | PIN1ALDH1A1SMN1; SMN2KMT2AMAPT | |
| SCHEMBL7364733 | 0.77 | EGFR (0.47) | CYP19A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3287938 | 0.77 | ALDH1A1 (0.62) | CYP19A1PIN1ALDH1A1SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380218-B1 | FOR THERAPY OF RESPIRATORY, ALLERGIC, AND INFLAMMATORY DISORDERS COMPRISING ASTHMA, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ACUTE RESPIRATORY DISEASE SYNDROME, PULMONARY HYPERSENSITIVITY, AND ALLERGIC RHINITIS IN A MAMMAL | PFIZER INC | 2002-04-30 | — | — | US | disclosed |
| EP-0971894-A1 | NICOTINAMIDE DERIVATIVES | Pfizer Products Inc. (US) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998045268-A1 | NICOTINAMIDE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 1998-10-15 | — | — | WO | disclosed |