Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.34 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.33 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.33 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.33 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 2/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.32 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL7367006 | 0.89 | SMN1; SMN2 (0.32) | SMN1; SMN2ALDH1A1CTBP2CA1CA2 | |
| Oxalic Acid SCHEMBL7364061 | 0.71 | KDM4E (0.37) | SMN1; SMN2KDM4EALDH1A1CTBP2GRIK2 | |
| Oxalic Acid SCHEMBL7401971 | 0.71 | KDM2B (0.44) | SMN1; SMN2KDM4EALDH1A1KDM2BGAA | |
| Oxalic Acid SCHEMBL7401973 | 0.71 | KDM2B (0.44) | SMN1; SMN2KDM4EALDH1A1KDM2BGAA | |
| SCHEMBL13268902 | 0.68 | SMN1; SMN2 (0.64) | SMN1; SMN2KDM4EALDH1A1PKMCA1 | |
| SCHEMBL28121003 | 0.67 | SMN1; SMN2 (0.58) | SMN1; SMN2KDM4EALDH1A1CTBP2PKM | |
| Oxalic Acid SCHEMBL7396176 | 0.65 | KDM2B (0.43) | SMN1; SMN2KDM4EALDH1A1KDM2BGAA | |
| Oxalic Acid SCHEMBL7396173 | 0.65 | KDM2B (0.43) | SMN1; SMN2KDM4EALDH1A1KDM2BGAA | |
| SCHEMBL7865663 | 0.64 | SMN1; SMN2 (0.54) | SMN1; SMN2KDM4EALDH1A1PKMPDE4B | |
| SCHEMBL7865659 | 0.64 | SMN1; SMN2 (0.54) | SMN1; SMN2KDM4EALDH1A1PKMPDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993019047-A1 | TETRAHIDROPYRIDINYL (3/4) SUBSTITUED OXIMES HAVING SIGMA RECEPTOR AFFINITY AND THEIR USE IN THE TREATMENT OF CENTRAL NERVOUS SYSTEM CONDITIONS | WARNER-LAMBERT COMPANY (US) | 1993-09-30 | — | — | WO | claimed |