Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | SENP2 | Q9HC62 | 1/20 | 0.49 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL257484 | 0.81 | KDM4E (0.50) | HPGDMEN1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL22232434 | 0.80 | MRGPRX4 (0.49) | HPGDTSHRMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL16382639 | 0.78 | MEN1 (0.48) | HPGDTSHRMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4842036 | 0.77 | SMN1; SMN2 (0.63) | MEN1KMT2ASMN1; SMN2RAB9AKDM4E | |
| SCHEMBL5000478 | 0.77 | LMNA (0.62) | HPGDTSHRSENP2SENP1MEN1 | |
| SCHEMBL5523413 | 0.76 | KMT2A (0.57) | HPGDTSHRSENP2SENP1MEN1 | |
| SCHEMBL101520 | 0.74 | PTGDR2 (0.68) | HPGDTSHRMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL3254718 | 0.74 | MEN1 (0.58) | HPGDTSHRSENP2SENP1MEN1 | |
| SCHEMBL2011265 | 0.74 | USP2 (0.58) | HPGDTSHRSENP2SENP1MEN1 | |
| SCHEMBL1515893 | 0.74 | SIGMAR1 (0.47) | RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380218-B1 | FOR THERAPY OF RESPIRATORY, ALLERGIC, AND INFLAMMATORY DISORDERS COMPRISING ASTHMA, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ACUTE RESPIRATORY DISEASE SYNDROME, PULMONARY HYPERSENSITIVITY, AND ALLERGIC RHINITIS IN A MAMMAL | PFIZER INC | 2002-04-30 | — | — | US | disclosed |
| EP-0971894-A1 | NICOTINAMIDE DERIVATIVES | Pfizer Products Inc. (US) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998045268-A1 | NICOTINAMIDE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 1998-10-15 | — | — | WO | disclosed |