Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | GYS1 | P13807 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6437669 | 0.84 | ROCK2 (0.48) | ALDH1A1PDK2 | |
| SCHEMBL7365360 | 0.76 | PLAU (0.52) | ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7368606 | 0.76 | PLAU (0.51) | ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7366138 | 0.76 | PLAU (0.51) | ALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL7372144 | 0.74 | CA1 (0.36) | CA2ITGB3ITGA2B | |
| SCHEMBL7370376 | 0.74 | PLAU (0.53) | ALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL6436057 | 0.73 | PLAU (0.42) | ALDH1A1CA2LOXL2ITGB3ITGA2B | |
| Trifluoroacetic Acid SCHEMBL6436061 | 0.73 | PLAU (0.42) | ALDH1A1CA2LOXL2ITGB3ITGA2B | |
| SCHEMBL7380961 | 0.71 | PLAU (0.52) | — | |
| Trifluoroacetic Acid SCHEMBL7444932 | 0.71 | F2 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242120-A2 | COMBINATIONS OF GROWTH FACTORS AND I:UPA OR I:MMP FOR THE TREATMENT OF DAMAGED TISSUE | Pfizer Limited (GB) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001049309-A2 | COMBINATIONS OF GROWTH FACTORS AND I: UPA OR I: MMP FOR THE TREATMENT OF DAMAGED TISSUE | PFIZER LIMITED (GB) | 2001-07-12 | — | — | WO | disclosed |
| EP-1077945-A1 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER INC. (US) | 2001-02-28 | — | — | EP | disclosed |
| WO-2000005214-A2 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER INC. (US) | 2000-02-03 | — | — | WO | disclosed |