Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCOA1 | Q15788 | 1/20 | 0.46 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TACR1 | P25103 | 4/20 | 0.41 |
| ▸ | KAT2B | Q92831 | 5/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7366633 | 0.91 | NCOA1 (0.46) | NCOA1NCOA3HPGDMEN1KMT2A | |
| SCHEMBL7360998 | 0.87 | HPGD (0.52) | HPGDMEN1KMT2AHTTKAT2B | |
| SCHEMBL7370202 | 0.86 | MKNK1 (0.44) | HPGDKMT2AGAAKAT2BALDH1A1 | |
| SCHEMBL7367931 | 0.84 | HPGD (0.55) | HPGDMEN1KMT2AKDM5BKAT2B | |
| SCHEMBL7367503 | 0.82 | HPGD (0.48) | NCOA1NCOA3HPGDMEN1KMT2A | |
| SCHEMBL7367402 | 0.82 | NCOA1 (0.46) | NCOA1NCOA3HPGDMEN1KMT2A | |
| SCHEMBL7370597 | 0.82 | L3MBTL1 (0.50) | KMT2ATACR1KAT2BCYP2C19ALDH1A1 | |
| SCHEMBL7370601 | 0.79 | SRC (0.46) | HPGDKAT2BCLK4ALDH1A1TP53 | |
| SCHEMBL7363597 | 0.79 | ALDH1A1 (0.51) | NCOA1NCOA3HPGDMEN1KMT2A | |
| SCHEMBL7369486 | 0.78 | KAT2B (0.49) | HPGDKMT2AKAT2BKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0612321-A1 | PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1994-08-31 | — | — | EP | disclosed |
| WO-1993007146-A1 | BENZO AND PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1993-04-15 | — | — | WO | disclosed |