Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | BMP1 | P13497 | 1/20 | 0.39 |
| ▸ | TAS2R14 | Q9NYV8 | 9/20 | 0.38 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.38 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.38 |
| ▸ | PTGES | O14684 | 1/20 | 0.37 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.37 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.37 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7049621 | 0.91 | PLAU (0.42) | ALDH1A1TAS2R14 | |
| SCHEMBL7377975 | 0.91 | PLAU (0.36) | ALDH1A1BMP1PTGER2 | |
| Hydrochloric Acid SCHEMBL7371889 | 0.91 | TAS2R14 (0.41) | ALDH1A1TAS2R14MEP1BPTGER2CXCR3 | |
| SCHEMBL6440602 | 0.90 | KEAP1 (0.45) | ALDH1A1TAS2R14MEP1BPTGESTAS2R8 | |
| SCHEMBL6434466 | 0.90 | NR1D1 (0.35) | — | |
| SCHEMBL7378340 | 0.88 | PDE4A (0.42) | ALDH1A1PTGER2CXCR3LMNA | |
| Hydrochloric Acid SCHEMBL7371405 | 0.86 | PLAU (0.38) | TAS2R14PTGER2CXCR3LMNA | |
| SCHEMBL6436322 | 0.85 | NR1D1 (0.37) | TAS2R14LMNATSHR | |
| SCHEMBL7378426 | 0.84 | PDE4A (0.39) | ALDH1A1CXCR3LMNA | |
| SCHEMBL7050063 | 0.84 | PLAU (0.38) | ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242120-A2 | COMBINATIONS OF GROWTH FACTORS AND I:UPA OR I:MMP FOR THE TREATMENT OF DAMAGED TISSUE | Pfizer Limited (GB) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001049309-A2 | COMBINATIONS OF GROWTH FACTORS AND I: UPA OR I: MMP FOR THE TREATMENT OF DAMAGED TISSUE | PFIZER LIMITED (GB) | 2001-07-12 | — | — | WO | disclosed |
| EP-1077945-A1 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER INC. (US) | 2001-02-28 | — | — | EP | disclosed |
| WO-2000005214-A2 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER INC. (US) | 2000-02-03 | — | — | WO | disclosed |