Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | DPP4 | P27487 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 2/20 | 0.37 |
| ▸ | CNR2 | P34972 | 2/20 | 0.37 |
| ▸ | NSD3 | Q9BZ95 | 1/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.36 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.36 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 3/20 | 0.35 |
| ▸ | CCND1 | P24385 | 3/20 | 0.35 |
| ▸ | CCND2 | P30279 | 3/20 | 0.35 |
| ▸ | CCND3 | P30281 | 3/20 | 0.35 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.35 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.35 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7371146 | 0.99 | ADORA1 (0.41) | ADORA1DPP4KCNH2CNR1CNR2 | |
| SCHEMBL7367704 | 0.91 | ADORA1 (0.40) | ADORA1DPP4KCNH2NSD3DPP8 | |
| SCHEMBL7367570 | 0.91 | NSD3 (0.48) | ADORA1DPP4KCNH2NSD3DPP8 | |
| SCHEMBL7365777 | 0.87 | ADORA1 (0.39) | ADORA1DPP4KCNH2NSD3DPP8 | |
| SCHEMBL7365779 | 0.87 | ADORA1 (0.39) | ADORA1DPP4KCNH2NSD3DPP8 | |
| SCHEMBL7668541 | 0.86 | ADORA1 (0.53) | ADORA1DPP4CNR1CNR2NSD3 | |
| SCHEMBL7373031 | 0.80 | ADORA1 (0.48) | ADORA1IGF1RMAPK1 | |
| SCHEMBL7663464 | 0.79 | ADORA1 (0.53) | ADORA1DPP4NSD3DPP8DPP9 | |
| SCHEMBL7364039 | 0.78 | ADORA1 (0.54) | ADORA1IGF1RMAPK1 | |
| SCHEMBL7486447 | 0.78 | NSD3 (0.52) | ADORA1DPP4NSD3DPP8DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244669-A1 | PYRAZOLOPYRAZINES AND THEIR USE AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001040230-A1 | PYRAZOLOPYRAZINES AND THEIR USE AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-06-07 | — | — | WO | disclosed |