Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | PDE9A | O76083 | 5/20 | 0.35 |
| ▸ | NSD3 | Q9BZ95 | 1/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | IGF1R | P08069 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7365779 | 0.94 | ADORA1 (0.39) | ADORA1DPP4KCNH2NSD3DPP8 | |
| SCHEMBL7365777 | 0.94 | ADORA1 (0.39) | ADORA1DPP4KCNH2NSD3DPP8 | |
| SCHEMBL7367701 | 0.91 | ADORA1 (0.42) | ADORA1DPP4KCNH2NSD3DPP8 | |
| SCHEMBL7371146 | 0.90 | ADORA1 (0.41) | ADORA1DPP4KCNH2NSD3DPP8 | |
| SCHEMBL7367570 | 0.88 | NSD3 (0.48) | ADORA1DPP4KCNH2NSD3DPP8 | |
| SCHEMBL7366165 | 0.85 | ADORA2A (0.38) | ADORA1MEN1CASP1CASP7KMT2A | |
| SCHEMBL7364072 | 0.84 | DPP4 (0.43) | DPP4KCNH2DPP8DPP9CYP1A2 | |
| SCHEMBL6818744 | 0.81 | BACE1 (0.39) | ADORA1DPP4PDE9ANSD3DPP8 | |
| SCHEMBL7373031 | 0.78 | ADORA1 (0.48) | ADORA1ALDH1A1KMT2AIGF1RGSK3B | |
| SCHEMBL7668541 | 0.77 | ADORA1 (0.53) | ADORA1DPP4NSD3DPP8DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244669-A1 | PYRAZOLOPYRAZINES AND THEIR USE AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001040230-A1 | PYRAZOLOPYRAZINES AND THEIR USE AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-06-07 | — | — | WO | disclosed |