Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | CTNNB1 | P35222 | 4/20 | 0.52 |
| ▸ | WNT3A | P56704 | 4/20 | 0.52 |
| ▸ | RAB9A | P51151 | 6/20 | 0.51 |
| ▸ | NPC1 | O15118 | 5/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | PKM | P14618 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | AGER | Q15109 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | IGFBP3 | P17936 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7367939 | 0.90 | SRD5A2 (0.57) | SRD5A2ALDH1A1MAPK1CTNNB1WNT3A | |
| SCHEMBL7365663 | 0.85 | SMN1; SMN2 (0.50) | SRD5A2ALDH1A1CTNNB1WNT3ARAB9A | |
| SCHEMBL8178878 | 0.83 | CTNNB1 (0.53) | SRD5A2ALDH1A1MAPK1CTNNB1WNT3A | |
| SCHEMBL7532873 | 0.82 | SRD5A2 (0.69) | SRD5A2ALDH1A1MAPK1CTNNB1WNT3A | |
| SCHEMBL7365580 | 0.80 | KMT2A (0.52) | SRD5A2ALDH1A1CTNNB1WNT3ARAB9A | |
| SCHEMBL9205751 | 0.80 | KDM4E (0.48) | ALDH1A1CTNNB1WNT3ANPC1KDM4E | |
| SCHEMBL7842348 | 0.78 | SRD5A2 (0.56) | SRD5A2ALDH1A1MAPK1CTNNB1WNT3A | |
| SCHEMBL13548377 | 0.77 | SRD5A2 (0.71) | SRD5A2ALDH1A1MAPK1CTNNB1WNT3A | |
| SCHEMBL7367595 | 0.77 | KDM4E (0.67) | SRD5A2ALDH1A1SMN1; SMN2KDM4ECYP3A4 | |
| SCHEMBL7526709 | 0.75 | ALDH1A1 (0.56) | SRD5A2ALDH1A1RAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0714897-B1 | FUSED HETEROAROMATIC CYCLOPENTENE DERIVATIVE HAVING ENDOTHELIN-ANTAGONIST ACTIVITY | BANYU PHARMA CO LTD (JP) | 2001-02-14 | — | — | EP | disclosed |
| CN-1049219-C | Fused heteroaromatic cyclopentene derivative having endothelin-antagonist activity | BANYU PHARMA CO LTD (JP) | 2000-02-09 | — | — | CN | disclosed |
| US-5716954-A | ANTIINFLAMMATORY AGENT, ANTIHISTAMINES, IMMUNOSUPPRESSION,AUTOIMMUNE DISEASES | SYNTEX U.S.A. INC. (US) | 1998-02-10 | — | — | US | disclosed |
| US-5714479-A | TREATMENT OF HYPERTENSION, ACUTE RENAL FAILURE, ANGINA PECTORIS, ARTERIOSCLEROSIS, ASTHMA, GASTRIC ULCER AND SIMILAR AILMENTS | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1998-02-03 | — | — | US | disclosed |
| CN-1129448-A | Fused heteroaromatic cyclopentene derivative having endothelin-antagonist activity | BANYU PHARMA CO LTD (JP) | 1996-08-21 | — | — | CN | disclosed |
| EP-0714897-A1 | FUSED HETEROAROMATIC CYCLOPENTENE DERIVATIVE HAVING ENDOTHELIN-ANTAGONIST ACTIVITY | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1996-06-05 | — | — | EP | disclosed |
| EP-0612321-A1 | PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1994-08-31 | — | — | EP | disclosed |
| WO-1993007146-A1 | BENZO AND PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1993-04-15 | — | — | WO | disclosed |