Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | AGER | Q15109 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | CTNNB1 | P35222 | 3/20 | 0.38 |
| ▸ | WNT3A | P56704 | 3/20 | 0.38 |
| ▸ | DHODH | Q02127 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | CDC25A | P30304 | 1/20 | 0.36 |
| ▸ | CDC25B | P30305 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | MYC | P01106 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7367755 | 0.80 | SRD5A2 (0.57) | KDM4EALDH1A1ALOX15CYP3A4MAPT | |
| SCHEMBL7367595 | 0.75 | KDM4E (0.67) | KDM4EALDH1A1ALOX15CYP3A4MAPT | |
| SCHEMBL3255990 | 0.74 | ALDH1A1 (0.52) | KDM4EALDH1A1ALOX15MAPTTSHR | |
| SCHEMBL6987666 | 0.74 | ALDH1A1 (0.61) | KDM4EALDH1A1ALOX15CYP3A4MAPT | |
| SCHEMBL7366799 | 0.73 | POLB (0.63) | KDM4EALDH1A1ALOX15CYP3A4MAPT | |
| SCHEMBL7526709 | 0.73 | ALDH1A1 (0.56) | KDM4EALDH1A1ALOX15CYP3A4MAPT | |
| SCHEMBL296670 | 0.73 | KDM4E (0.69) | KDM4EALDH1A1ALOX15CYP3A4MAPT | |
| SCHEMBL9635664 | 0.72 | KDM4E (0.80) | KDM4EALDH1A1ALOX15CYP3A4MAPT | |
| Hydrochloric Acid SCHEMBL7853761 | 0.72 | KDM4E (0.67) | KDM4EALDH1A1ALOX15CYP3A4MAPT | |
| SCHEMBL7364079 | 0.71 | KDM4E (0.61) | KDM4EALDH1A1ALOX15CYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0341948-B1 | Cephalosporins, process for their preparation and pharmaceutical compositions | ICI PLC (GB) | 1995-01-11 | — | — | EP | disclosed |
| US-5149803-A | Intermediates for cephalosporin compounds | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-09-22 | — | — | US | disclosed |
| US-5055462-A | CEPHALOSPORIN COMPOUNDS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-10-08 | — | — | US | disclosed |
| EP-0341948-A2 | Cephalosporins, process for their preparation and pharmaceutical compositions | ZENECA LIMITED (GB) | 1989-11-15 | — | — | EP | disclosed |