Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K4 | P45985 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.45 |
| ▸ | MMP9 | P14780 | 1/20 | 0.45 |
| ▸ | MMP8 | P22894 | 1/20 | 0.45 |
| ▸ | MMP13 | P45452 | 1/20 | 0.45 |
| ▸ | ATIC | P31939 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | HSPD1 | P10809 | 4/20 | 0.42 |
| ▸ | PTPN2 | P17706 | 4/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.42 |
| ▸ | PTPN5 | P54829 | 4/20 | 0.42 |
| ▸ | HSPE1 | P61604 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7370197 | 0.92 | MMP2 (0.48) | MAP2K4MMP2MMP9MMP8MMP13 | |
| SCHEMBL7369834 | 0.88 | MAPT (0.47) | MAP2K4MMP2MMP9MMP8MMP13 | |
| SCHEMBL7372182 | 0.84 | MMP2 (0.49) | MMP2MMP9MMP8MMP13MAPT | |
| SCHEMBL7375348 | 0.81 | NPC1 (0.49) | MMP2MMP9MMP8MMP13MAPT | |
| SCHEMBL7376435 | 0.80 | MEN1 (0.50) | MAPTTP53SMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL7371315 | 0.77 | PTPN2 (0.54) | MAP2K4MAPTHSPD1PTPN2PTPN1 | |
| SCHEMBL7372718 | 0.76 | MAPT (0.44) | MMP2MMP9MMP8MMP13MAPT | |
| SCHEMBL7370125 | 0.76 | MAPT (0.49) | MMP2MMP9MMP8MMP13MAPT | |
| SCHEMBL6925701 | 0.74 | MAPT (0.62) | MAP2K4MMP2MMP9MMP8MMP13 | |
| SCHEMBL16147276 | 0.73 | MMP2 (0.78) | MMP2MMP9MMP8MMP13ATIC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001074786-A1 | HETEROBIARYLSULPHONAMIDES AND THEIR USE AS PDE 7 INHIBITORS | DARWIN DISCOVERY LIMITED (GB) | 2001-10-11 | — | — | WO | claimed |
| WO-2001074786-A1 | HETEROBIARYLSULPHONAMIDES AND THEIR USE AS PDE 7 INHIBITORS | DARWIN DISCOVERY LIMITED (GB) | 2001-10-11 | — | — | WO | disclosed |