Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 1/20 | 0.48 |
| ▸ | MMP9 | P14780 | 1/20 | 0.48 |
| ▸ | MMP8 | P22894 | 1/20 | 0.48 |
| ▸ | MMP13 | P45452 | 1/20 | 0.48 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.44 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.44 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.40 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.40 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.39 |
| ▸ | SGK1 | O00141 | 2/20 | 0.39 |
| ▸ | ATIC | P31939 | 1/20 | 0.39 |
| ▸ | BRD1 | O95696 | 1/20 | 0.39 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7367756 | 0.92 | MAP2K4 (0.47) | MMP2MMP9MMP8MMP13HSPD1 | |
| SCHEMBL7372182 | 0.83 | MMP2 (0.49) | MMP2MMP9MMP8MMP13HSPD1 | |
| SCHEMBL7369834 | 0.83 | MAPT (0.47) | MMP2MMP9MMP8MMP13HSPD1 | |
| SCHEMBL7375348 | 0.77 | NPC1 (0.49) | MMP2MMP9MMP8MMP13TP53 | |
| SCHEMBL7376435 | 0.76 | MEN1 (0.50) | TP53MAPT | |
| SCHEMBL7372718 | 0.76 | MAPT (0.44) | MMP2MMP9MMP8MMP13KDM1A | |
| SCHEMBL7370125 | 0.76 | MAPT (0.49) | MMP2MMP9MMP8MMP13HSPD1 | |
| SCHEMBL16147276 | 0.73 | MMP2 (0.78) | MMP2MMP9MMP8MMP13HSPD1 | |
| SCHEMBL14632373 | 0.71 | L3MBTL1 (0.61) | MMP2MMP9MMP8MMP13HSPD1 | |
| SCHEMBL1895139 | 0.70 | MEN1 (0.56) | MMP2MMP9MMP8MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001074786-A1 | HETEROBIARYLSULPHONAMIDES AND THEIR USE AS PDE 7 INHIBITORS | DARWIN DISCOVERY LIMITED (GB) | 2001-10-11 | — | — | WO | claimed |
| WO-2001074786-A1 | HETEROBIARYLSULPHONAMIDES AND THEIR USE AS PDE 7 INHIBITORS | DARWIN DISCOVERY LIMITED (GB) | 2001-10-11 | — | — | WO | disclosed |