Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 7/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.41 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7376435 | 0.88 | MEN1 (0.50) | NPC1RAB9AGAAMAPTCHEK2 | |
| SCHEMBL7369834 | 0.83 | MAPT (0.47) | MAPTCHEK2MEN1KMT2AMMP2 | |
| SCHEMBL7367756 | 0.81 | MAP2K4 (0.47) | GAAMAPTCHEK2MEN1KMT2A | |
| SCHEMBL7372182 | 0.80 | MMP2 (0.49) | MAPTMEN1KMT2AALDH1A1MMP2 | |
| SCHEMBL7370197 | 0.77 | MMP2 (0.48) | MAPTMMP2MMP9MMP8MMP13 | |
| SCHEMBL7451273 | 0.74 | POLB (0.77) | NPC1RAB9AGAAPOLBMAPT | |
| SCHEMBL7372718 | 0.74 | MAPT (0.44) | MAPTMEN1KMT2AALDH1A1MMP2 | |
| SCHEMBL7370125 | 0.72 | MAPT (0.49) | MAPTCHEK2MEN1KMT2AMMP2 | |
| SCHEMBL7375504 | 0.69 | MEN1 (0.65) | NPC1RAB9AMAPTMEN1KMT2A | |
| SCHEMBL7941257 | 0.68 | KMT2A (0.54) | NPC1RAB9AGAACHEK2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001074786-A1 | HETEROBIARYLSULPHONAMIDES AND THEIR USE AS PDE 7 INHIBITORS | DARWIN DISCOVERY LIMITED (GB) | 2001-10-11 | — | — | WO | claimed |
| WO-2001074786-A1 | HETEROBIARYLSULPHONAMIDES AND THEIR USE AS PDE 7 INHIBITORS | DARWIN DISCOVERY LIMITED (GB) | 2001-10-11 | — | — | WO | disclosed |