Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.63 |
| ▸ | HPGD | P15428 | 1/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.63 |
| ▸ | ELANE | P08246 | 1/20 | 0.61 |
| ▸ | PRTN3 | P24158 | 1/20 | 0.61 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.60 |
| ▸ | TSHR | P16473 | 3/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | RECQL | P46063 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 4/20 | 0.59 |
| ▸ | TP53 | P04637 | 2/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6709802 | 0.87 | TSHR (0.67) | LMNAKDM4EALDH1A1HPGDMAPK1 | |
| SCHEMBL4443911 | 0.85 | ALOX5 (0.63) | LMNAKDM4EALDH1A1MAPK1ABCG2 | |
| SCHEMBL9575455 | 0.84 | KDM4E (0.80) | LMNAKDM4EALDH1A1HPGDMAPK1 | |
| SCHEMBL31730773 | 0.84 | KDM4E (0.80) | LMNAKDM4EALDH1A1HPGDMAPK1 | |
| SCHEMBL8239760 | 0.83 | SMN1; SMN2 (0.56) | LMNAKDM4EALDH1A1HPGDMAPK1 | |
| SCHEMBL3506460 | 0.83 | SMN1; SMN2 (0.61) | LMNAKDM4EALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL14855876 | 0.82 | ALDH1A1 (0.72) | LMNAKDM4EALDH1A1MAPK1ABCG2 | |
| SCHEMBL10325817 | 0.82 | KDM4E (0.76) | LMNAKDM4EALDH1A1HPGDMAPK1 | |
| SCHEMBL14855680 | 0.82 | KDM4E (0.76) | LMNAKDM4EALDH1A1HPGDMAPK1 | |
| SCHEMBL7372951 | 0.82 | KMT2A (0.69) | LMNAALDH1A1MAPK1ABCG2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6211242-B1 | CARDIOVASCULAR DISORDERS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-04-03 | — | — | US | disclosed |
| EP-0757670-B1 | BENZAMIDE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO (JP) | 1999-01-13 | — | — | EP | disclosed |
| US-5728835-A | HYPOTENSIVE AGENTS; ANTIISCHEMIC AGENTS | TOA EIYO, LTD. (JP) | 1998-03-17 | — | — | US | disclosed |
| WO-1995029152-A1 | BENZAMIDE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-11-02 | — | — | WO | disclosed |
| EP-0661266-A1 | Substituted cyclic amine compounds as 5HT2 antagonists | TOA EIYO LTD. (JP) | 1995-07-05 | — | — | EP | disclosed |